Adrenergic alpha-Antagonists Adult Aged Bias Cholinergic Antagonists Drug Therapy Combination Humans Lower Urinary Tract Symptoms Male Middle Aged Prostatic Hyperplasia Quality of Life Randomized Controlled Trials as Topic

Adrenergic alpha-Antagonists/*administration & dosage/pharmacology Drug Interactions Drug Therapy Combination Erectile Dysfunction/complications/*drug therapy/physiopathology Hemodynamics/*drug effects Humans Lower Urinary Tract Symptoms/complications/*drug therapy/physiopathology Male Phosphodiesterase 5 Inhibitors/*administration & dosage/pharmacology Prostatic Hyperplasia/complications/*drug therapy/physiopathology Randomized Controlled Trials as Topic Alpha blocker Benign prostatic hyperplasia Erectile dysfunction Hemodynamic interaction Luts Phosphodiesterase-5 inhibitors

Aged Drug Therapy Combination Erectile Dysfunction/*drug therapy Humans Male Middle Aged Phosphodiesterase Inhibitors Prostatic Hyperplasia/*drug therapy Tadalafil Tamsulosin Treatment Outcome Vasodilator Agents *benign prostatic hyperplasia *erectile dysfunction *meta-analysis *tadalafil *tamsulosin conflicts of interest with respect to the research authorship and/or publication of this article.

5-alpha Reductase Inhibitors/*administration & dosage Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Drug Therapy Combination Dutasteride/*administration & dosage Erectile Dysfunction/chemically induced/diagnosis Humans Male Prostatic Hyperplasia/diagnosis/*drug therapy/epidemiology Randomized Controlled Trials as Topic/methods Tamsulosin/*administration & dosage Treatment Outcome Benign prostatic hyperplasia Dutasteride Meta-analysis Randomized controlled trials Tamsulosin published studies thus no ethical approval and patient consent are required. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Adrenergic beta-3 Receptor Agonists/administration & dosage Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans Lower Urinary Tract Symptoms/*drug therapy Male Phosphodiesterase 5 Inhibitors/*administration & dosage Prostatic Hyperplasia/complications Quality of Life Randomized Controlled Trials as Topic 5-alpha reductase inhibitor Lower urinary tract symptoms alpha blockers anticholinergic: systematic review benign prostatic hyperplasia randomized trials

Adrenergic alpha-Antagonists Drug Therapy Combination Humans Lower Urinary Tract Symptoms Male Middle Aged Phosphodiesterase Inhibitors Prostatic Hyperplasia Randomized Controlled Trials as Topic

Adrenergic alpha-Antagonists Benzilates Drug Combinations Ethamsylate Humans Indoles Lower Urinary Tract Symptoms Male Naphthalenes Piperazines Plant Extracts Prostatic Hyperplasia Prostatism Quality of Life Randomized Controlled Trials as Topic Sulfonamides Tamsulosin Urological Agents

Adrenergic alpha-Antagonists/administration & dosage/*therapeutic use Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans *Lower Urinary Tract Symptoms Male Prostatic Hyperplasia/*diagnosis/*drug therapy Publication Bias Quality of Life Treatment Outcome

5-alpha Reductase Inhibitors/*adverse effects Drug Therapy Combination Ejaculation/drug effects Erectile Dysfunction/*chemically induced/drug therapy Finasteride Humans Libido/*drug effects Male Middle Aged Prostatic Hyperplasia/*drug therapy Randomized Controlled Trials as Topic *5α-Reductase Inhibitors *Erectile Dysfunction *Meta-Analysis *Sexual Dysfunction