Adult *Amino Acid Substitution Case-Control Studies DNA-Binding Proteins/*genetics Female Gene Expression *Genetic Predisposition to Disease Humans Male Middle Aged Odds Ratio *Polymorphism Single Nucleotide Risk Factors Smoking/physiopathology Tobacco Use/physiopathology Urinary Bladder Neoplasms/diagnosis/*genetics/pathology

Adult Aged Aged 80 and over Antibodies Monoclonal/therapeutic use Antibodies Monoclonal Humanized/therapeutic use B7-H1 Antigen/*antagonists & inhibitors/genetics CTLA-4 Antigen/*antagonists & inhibitors/genetics Clinical Trials as Topic Female Genes cdc/drug effects Humans Ipilimumab Male Middle Aged Neoplasm Metastasis/*drug therapy/genetics/pathology Nivolumab Urinary Bladder Neoplasms/*drug therapy/genetics/pathology Bladder cancer immunotherapy Checkpoint inhibitor Pembrolizumab

Adult Aged Aged 80 and over Female *Fluorodeoxyglucose F18 Humans Lymphatic Metastasis Male Middle Aged Neoplasm Staging *Positron Emission Tomography Computed Tomography *Radiopharmaceuticals Reproducibility of Results Retrospective Studies Urinary Bladder Neoplasms/*drug therapy/*pathology Bladder cancer Lymph nodes Positron emission tomography Preoperative staging Urinary bladder neoplasms

Adult Aged Aged 80 and over Biomarkers Tumor/*metabolism Cyclin-Dependent Kinase Inhibitor p16/*metabolism *Down-Regulation Female Gene Expression Regulation Neoplastic Humans Lymphatic Metastasis Male Middle Aged Prognosis Survival Analysis Urinary Bladder Neoplasms/metabolism/mortality/*pathology