Humans *Urinary Diversion/adverse effects *Ureter/surgery Cystectomy/methods Anastomosis Surgical/adverse effects *Vesico-Ureteral Reflux/etiology *Urinary Bladder Neoplasms/surgery Ileum/surgery *Pyelonephritis/complications Bladder Orthotopic ileal neobladder Radical cystectomy Tumor Ureteroenteric anastomosis Urinary diversion

Humans *Urinary Bladder/pathology Cystectomy/methods Prognosis Prospective Studies Neoplasm Recurrence Local/pathology *Urinary Bladder Neoplasms/pathology Biomarkers biomarker neutrophil-to-lymphocyte ratio prognostic factor radical cystectomy recurrence urothelial carcinoma

Cystectomy/methods Humans Quality of Life *Urinary Bladder Neoplasms/surgery *Urinary Diversion/methods *Urinary Reservoirs Continent nursing systematic review urinary diversion

Adult Carotenoids Female Humans Lutein Male *Urinary Bladder Neoplasms/epidemiology/prevention & control Zeaxanthins beta Carotene bladder cancer blood diet lycopene zeaxanthin α-carotene β-carotene β-cryptoxanthin

Cystectomy/adverse effects Humans Postoperative Complications/diagnosis/epidemiology/etiology Risk Factors *Robotic Surgical Procedures/adverse effects *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery Urologic Surgical Procedures *Urology Complications European Association of Urology guidelines Outcome reporting Robot-assisted radical cystectomy Standardised tool

Biomarkers/urine DNA Mutational Analysis DNA Neoplasm/*urine Disease Progression Humans Mutation Neoplasm Recurrence Local/*diagnosis/genetics/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/genetics/*urine #BladderCancer #blcsm biomarkers molecular diagnostics urinary bladder neoplasms urine analysis Amsterdam UMC location VUmc. J. Bosschieter R.D.M. Steenbergen and J.A. Nieuwenhuijzen are inventors on patent(s) related to the work.

Anesthetics Local/*therapeutic use *Cystoscopy Humans Lidocaine/*therapeutic use Male Pain Management/*methods Pain Measurement Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/diagnosis/therapy administration cystoscopy intravesical lidocaine pain procedural urinary bladder neoplasms

Carcinoma Transitional Cell/diagnosis/epidemiology/*therapy Child Combined Modality Therapy *Disease Management Disease Progression Global Health Humans Incidence Risk Factors Survival Rate/trends Urinary Bladder/*pathology Urinary Bladder Neoplasms/diagnosis/epidemiology/*therapy Management Pediatric Surveillance Transurethral resection Urothelial cell carcinoma

Arylamine N-Acetyltransferase/*genetics Genotype Humans Isoenzymes/*genetics Phenotype Polymorphism Genetic Urinary Bladder Neoplasms/*enzymology/*genetics N-Acetyltransferase Nat1 genetic polymorphism meta-analysis smoking systematic review urinary bladder cancer