首页膀胱肿瘤治疗及预后证据详情

Efficacy and Safety of Transurethral Laser Surgery Versus Transurethral Resection for Non-Muscle-Invasive Bladder Cancer: A Meta-Analysis and Systematic Review

原文: 2020 年 发布于 Eur Urol Oncol 25 卷 第 12 期 1-7 浏览量:201次

作者: Xu J. N. Wang C. Ouyang J. Sun J. L. Hu C.

作者单位: Department of Urology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Department of mechanical engineering, National University of Singapore, Kent Ridge, Singapore. Department of Urology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: shushengwanggzy@163.com.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1007/s11701-020-01174-4

关键词: Carcinoma Transitional Cell/diagnosis/epidemiology/*therapy Child Combined Modality Therapy *Disease Management Disease Progression Global Health Humans Incidence Risk Factors Survival Rate/trends Urinary Bladder/*pathology Urinary Bladder Neoplasms/diagnosis/epidemiology/*therapy Management Pediatric Surveillance Transurethral resection Urothelial cell carcinoma

文献简介

Background This study aimed to evaluate the diagnostic value of telomerase activity (TA) for bladder cancer (BC) by meta-analysis. Methods We conducted a systematic search of studies published on PubMed, Embase, and Web of Science up to June 1, 2019. We used Stata 15 and Review Manager 5.3 for calculations and statistical analysis. Results To evaluate the diagnostic value of TA for BC, we performed a meta-analysis on 22 studies, with a total of 2,867 individuals, including sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR), and 95% confidence intervals (CIs). The pooled parameters were calculated from all studies, and we found a sensitivity of 0.79 (95% CI: 0.72-0.84), a specificity of 0.91 (95% CI: 0.87-0.94), a PLR of 8.91 (95% CI: 5.91-13.43), an NLR of 0.24 (95% CI: 0.15-0.37), a DOR of 37.90 (95% CI: 23.32-61.59), and an AUC of 0.92 (95% CI: 0.90-0.94). We also conducted a subgroup analysis based on the different stages and grades of BC. Results from the subgroup analysis showed that there was no significant difference in TA in either high and low stages of BC, but that low-grade tumors had a lower TA than high-grade tumours. Conclusions TA can be used as a potential biomarker for the diagnosis of bladder cancer with its high specificity. Rigorous and high-quality prospective studies are required to verify our conclusion.

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