Urinary human papilloma virus infection and bladder cancer risk: A systematic review and a prisma-compliant meta-analysis

原文： 2022 年发布于 Int J Nurs Pract 13 卷第 4 期 678-684  浏览量：785次

作者： Garcia-Rojo D. Munoz-Rodriguez J. Centeno C. Dominguez A. Prera A. Abad C. Vicente E. Gonzalez-Sala J. L. Hannaoui N. Capdevila M. De Verdonces L. Ferran A. Pla C. Azuara P. Cuadrench S. Zegri M. E. Prats J.

作者单位： Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia. Monash University, Department of Medicine, The Wollongong Hospital, NSW, Australia. Department of Urology, The Wollongong Hospital, NSW, Australia. Department of Urology, The Wollongong Hospital, NSW, Australia. Electronic address: akshat16187@gmail.com.

归属分类：膀胱肿瘤病因/危险因素证据

DOI： 10.1186/s12894-018-0382-z

关键词：非肌层浸润性膀胱癌卡介苗维持治疗诱导治疗

INTRODUCTION: We performed a meta-analysis to evaluate the effect of en-bloc transurethral resection vs. conventional transurethral resection for primary non-muscle invasive bladder cancer. METHODS: A systematic literature search up to January 2022 was done and 28 studies included 3714 primary non-muscle invasive bladder cancer subjects at the start of the study; 1870 of them were en-bloc transurethral resection, and 1844 were conventional transurethral resection for primary non-muscle invasive bladder cancer. We calculated the odds-ratio (OR) and mean-difference (MD) with 95% confidence-intervals (CIs) to evaluate the effect of en-bloc transurethral resection compared with conventional transurethral resection for primary non-muscle invasive bladder cancer by the dichotomous or continuous methods with random or fixed-effects models. RESULTS: En-bloc transurethral resection had significantly lower twenty-four-month recurrence (OR: 0.63; 95%CI: 0.50-0.78; p < 0.001), catheterization-time (MD: -0.66; 95%CI: -1.02-[-0.29]; p < 0.001), length of hospital stay (MD: -0.95; 95%CI: -1.55-[-0.34]; p = 0.002), postoperative bladder irrigation duration (MD: -6.06; 95%CI: -9.45-[-2.67]; p < 0.001), obturator nerve reflex (OR: 0.08; 95%CI: 0.02-0.34; p = 0.03), and bladder perforation (OR: 0.14; 95%CI: 0.06-0.36: p < 0.001) and no significant difference in the 12-month-recurrence (OR: 0.79; 95%CI: 0.61-1.04; p = 0.09), the operation time (MD: 0.67; 95%CI: -1.92 to 3.25; p = 0.61), and urethral stricture (OR: 0.46; 95%CI: 0.14-1.47; p = 0.0.19) compared with conventional transurethral resection for primary non-muscle invasive bladder cancer subjects. CONCLUSIONS: En-bloc transurethral resection had a significantly lower twenty-four-month recurrence, catheterization time, length of hospital stay, postoperative bladder irrigation duration, obturator nerve reflex, bladder perforation, and no significant difference in the twelve-month recurrence, operation time, and urethral stricture compared with conventional transurethral resection for primary non-muscle invasive bladder cancer subjects. Further studies are required.