Humans Lower Urinary Tract Symptoms Male Network Meta-Analysis Phytotherapy Plant Extracts Prostate/*drug effects Prostatic Hyperplasia/*drug therapy Randomized Controlled Trials as Topic *Serenoa Treatment Outcome *Benign prostatic hyperplasia *Lower urinary tract symptoms *Medical therapy *Phytotherapy *Prostate *Saw palmetto

5-alpha Reductase Inhibitors/administration & dosage/*adverse effects Alopecia/drug therapy Depression/*chemically induced/epidemiology Finasteride/administration & dosage/*adverse effects Humans Male Prostatic Hyperplasia/drug therapy Sexual Dysfunction Physiological/chemically induced/epidemiology Suicidal Ideation

5-alpha Reductase Inhibitors Androgen Antagonists Humans Male Plant Extracts/*pharmacology *Prostatic Hyperplasia/drug therapy Randomized Controlled Trials as Topic *Serenoa/chemistry Tamsulosin

5-alpha Reductase Inhibitors Humans Male Oxidoreductases Prospective Studies *Prostatic Hyperplasia/drug therapy *Prostatic Neoplasms/drug therapy 5?-reductase inhibitors Bph Prostate cancer cancer specific mortality meta-analysis

Adrenergic alpha-Antagonists Adult Aged Bias Cholinergic Antagonists Drug Therapy Combination Humans Lower Urinary Tract Symptoms Male Middle Aged Prostatic Hyperplasia Quality of Life Randomized Controlled Trials as Topic

Acetanilides Adrenergic beta-3 Receptor Agonists Aged Humans Lower Urinary Tract Symptoms Male Prostatic Hyperplasia/complications/*drug therapy Randomized Controlled Trials as Topic Thiazoles Treatment Outcome Urinary Bladder Overactive/complications/*drug therapy Urological Agents Lower urinary tract symptoms Mirabegron Overactive Prostatic hyperplasia Urinary bladder

Animals Humans *Lower Urinary Tract Symptoms/drug therapy Male Prostatic Hyperplasia/therapy Urinary Bladder Overactive/complications *Urothelium/physiopathology

Aged Aged 80 and over Humans Male Middle Aged Outcome Assessment Health Care Plant Extracts/administration & dosage Prostatic Hyperplasia/*drug therapy Serenoa Tamsulosin/administration & dosage Urological Agents/administration & dosage *Serenoa repens *benign prostatic hyperplasia *meta-analysis *randomized controlled trials *tamsulosin conflicts of interest with respect to the research authorship and/or publication of this article.

Adrenergic alpha-Antagonists/*administration & dosage/pharmacology Drug Interactions Drug Therapy Combination Erectile Dysfunction/complications/*drug therapy/physiopathology Hemodynamics/*drug effects Humans Lower Urinary Tract Symptoms/complications/*drug therapy/physiopathology Male Phosphodiesterase 5 Inhibitors/*administration & dosage/pharmacology Prostatic Hyperplasia/complications/*drug therapy/physiopathology Randomized Controlled Trials as Topic Alpha blocker Benign prostatic hyperplasia Erectile dysfunction Hemodynamic interaction Luts Phosphodiesterase-5 inhibitors

Aged Drug Therapy Combination Erectile Dysfunction/*drug therapy Humans Male Middle Aged Phosphodiesterase Inhibitors Prostatic Hyperplasia/*drug therapy Tadalafil Tamsulosin Treatment Outcome Vasodilator Agents *benign prostatic hyperplasia *erectile dysfunction *meta-analysis *tadalafil *tamsulosin conflicts of interest with respect to the research authorship and/or publication of this article.

5-alpha Reductase Inhibitors/*administration & dosage Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Drug Therapy Combination Dutasteride/*administration & dosage Erectile Dysfunction/chemically induced/diagnosis Humans Male Prostatic Hyperplasia/diagnosis/*drug therapy/epidemiology Randomized Controlled Trials as Topic/methods Tamsulosin/*administration & dosage Treatment Outcome Benign prostatic hyperplasia Dutasteride Meta-analysis Randomized controlled trials Tamsulosin published studies thus no ethical approval and patient consent are required. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Female Humans Lower Urinary Tract Symptoms/*drug therapy Male Prostatic Hyperplasia/complications/*drug therapy Randomized Controlled Trials as Topic Sexual Dysfunction Physiological Treatment Outcome

Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Adrenergic beta-3 Receptor Agonists/administration & dosage Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans Lower Urinary Tract Symptoms/*drug therapy Male Phosphodiesterase 5 Inhibitors/*administration & dosage Prostatic Hyperplasia/complications Quality of Life Randomized Controlled Trials as Topic 5-alpha reductase inhibitor Lower urinary tract symptoms alpha blockers anticholinergic: systematic review benign prostatic hyperplasia randomized trials

Capsules Drugs Chinese Herbal Humans Male Prostatic Hyperplasia/*drug therapy Randomized Controlled Trials as Topic Treatment Outcome Urinary Retention benign prostatic hyperplasia meta-analysis randomized controlled trial systematic review Qianlieshutong Capsules

Administration Oral Chronic Disease Flowers/physiology Humans Male Medicine Traditional Phytotherapy Plant Extracts/*administration & dosage Pollen/*physiology Prostatic Hyperplasia/drug therapy Prostatitis/drug therapy Treatment Outcome clinical practice efficacy evidence-based complementary and alternative medicine phytotherapy pollen review

Adrenergic alpha-Antagonists Doxazosin Humans Indoles Male Network Meta-Analysis Prostatic Hyperplasia/*drug therapy Quality of Life Sexual Dysfunction Physiological/chemically induced Tamsulosin adverse event alpha adrenergic receptor antagonist benign prostatic hyperplasia

Disease Progression Humans Lower Urinary Tract Symptoms/etiology Male Prostatic Hyperplasia/complications/*drug therapy Risk Factors Time Factors Treatment Outcome Benign prostatic hyperplasia Early treatment Luts Outcomes complications Pharmacological treatment Prostate Surgery

Adrenergic alpha-Antagonists Drug Therapy Combination Humans Lower Urinary Tract Symptoms Male Middle Aged Phosphodiesterase Inhibitors Prostatic Hyperplasia Randomized Controlled Trials as Topic

Adrenergic alpha-Antagonists/administration & dosage/*therapeutic use Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans *Lower Urinary Tract Symptoms Male Prostatic Hyperplasia/*diagnosis/*drug therapy Publication Bias Quality of Life Treatment Outcome

5-alpha Reductase Inhibitors/*adverse effects Drug Therapy Combination Ejaculation/drug effects Erectile Dysfunction/*chemically induced/drug therapy Finasteride Humans Libido/*drug effects Male Middle Aged Prostatic Hyperplasia/*drug therapy Randomized Controlled Trials as Topic *5α-Reductase Inhibitors *Erectile Dysfunction *Meta-Analysis *Sexual Dysfunction