首页良性前列腺增生治疗及预后证据详情

Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging

原文:2022年 发布于 Front Immunol 浏览量:1296次 原文链接

作者: Cao D. Sun R. Peng L. Li J. Huang Y. Chen Z. Chen B. Li J. Ai J. Yang L. Liu L. Wei Q.

作者单位: Department of Urology, West China Hospital, Sichuan University, Chengdu, China. Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. West China School of Medicine, Sichuan University, Chengdu, China. Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, China.

归属分类: 良性前列腺增生治疗及预后证据

DOI: 10.3389/fimmu.2022.842008

关键词: Aging Androgens/metabolism Anti-Inflammatory Agents Humans Inflammation Male *Prostatic Hyperplasia benign prostatic hyperplasia disease progression pathogenesis commercial or financial relationships that could be construed as a potential conflict of interest.

文献简介

To review the role of inflammation in the occurrence and development of benign prostatic hyperplasia (BPH), we searched PubMed for the latest published articles up to February 2021 using the following key words: "benign prostatic hyperplasia", "inflammation", "pathogenesis" and "disease development". Articles were obtained and reviewed to provide a systematic review of the current progress of the role of inflammation in the pathogenesis and progression of BPH. Inflammation contributes to the initiation and maintenance of unregulated cell proliferation and is closely related to the occurrence and development of BPH. Its action pathways include tissue damage and subsequent chronic healing, autoimmunity, and coaction with androgens. During the progression of inflammation, macrophages, interleukin-8 (IL-8), interleukin-1 (IL-1) and other inflammatory-related substances aggregate locally and cause BPH through various biochemical pathways. At the same time, BPH can also counteract inflammation to expand its scope and aggravate the situation. Inflammation can independently affect the development of BPH in a variety of ways, and it can also interact with androgens. In the course of treatment, early intervention in the occurrence and development of inflammation in prostate tissue can slow down the progression of BPH. The combination of standard therapies and anti-inflammatory measures may provide valuable new ideas for the treatment of BPH.

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