The recurrence and progression risk after simultaneous endoscopic surgery of urothelial bladder tumour and benign prostatic hyperplasia: a systematic review and meta-analysis
原文：2021年 发布于
BJU Int
127卷 第2期 143-152
浏览量：1135次
原文链接
作者：
Sari Motlagh
R. Mori
K. Miura
N. Quhal
F. Aydh
A. Laukhtina
E. Pradere
B. Karakiewicz
P. I. Enikeev
D. V. Deuker
M. Shariat
S. F.
作者单位：
Department of Urology, Medical University of Vienna, Vienna, Austria.
Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Department of Urology, Ehime University Graduate School of Medicine, Ehime, Japan.
King Fahad Specialist Hospital, Dammam, Saudi Arabia.
King Faisal Medical City, Abha, Saudi Arabia.
Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.
Department of Urology, University Hospital of Tours, Tours, France.
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada.
Department of Urology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Department of Urology, Weil Cornell Medical College, New York, NY, USA.
Department of Urology, University of Texas Southwestern, Dallas, TX, USA.
Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria.
Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.
European Association of Urology Research Foundation, Arnhem, The Netherlands.
归属分类：
良性前列腺增生治疗及预后证据
DOI：
10.1111/bju.15146
关键词：
Cystectomy/*adverse effects
Humans
Male
Neoplasm Recurrence
Local/*diagnosis
Prostatic Hyperplasia/diagnosis
Transurethral Resection of Prostate/*adverse effects
Urinary Bladder/*diagnostic imaging
Urinary Bladder Neoplasms/diagnosis
*#BladderCancer
*#blcsm
*Turbt
*Turp
*benign prostatic hyperplasia
*bladder cancer
*endoscopic surgery
*simultaneous surgery
OBJECTIVES: To evaluate recurrence and progression risk after simultaneous endoscopic surgery of bladder cancer and benign prostatic hyperplasia (BPH), as simultaneous surgery is not an unusual scenario and theoretically simultaneous transurethral resection of bladder tumour (TURBT) and transurethral resection of the prostate (TURP) can lead to an increased risk of recurrence in the bladder neck and prostatic urethra (BN/PU). METHODS: We conducted a systematic review and meta-analysis to assess the risk of recurrence (i.e. whole bladder and/or BN/PU) and tumour progression as outcomes after a simultaneous endoscopic surgery of bladder tumour and BPH, as compared to TURBT alone. We queried PubMed and Web of Science database on 1 January 2020. We used random- and/or fixed-effects meta-analytic models in the presence or absence of heterogeneity according to the I(2) statistic, respectively. RESULTS: Nine retrospective and three clinical trial studies were selected after considering inclusion and exclusion criteria. We conducted the meta-analysis on retrospective and randomised controlled trials (RCTs) separately. Eight retrospective and three RCT studies were included to assess the BN/PU recurrence risk and the summarised risk ratio (RR) was 1.02 (95% confidence interval [CI] 0.74-1.41) and 0.93 (95% CI 0.47-1.84), respectively. Five retrospective and two RCT studies were included to assess the progression risk and the summarised RR was 0.91 (95% CI 0.56-1.48) and 1.16 (95% CI 0.30-4.51), respectively. Eight retrospective and three RCT studies were included to assess the whole bladder recurrence risk and the summarised RR was 0.87 (95% CI 0.78-0.97) and 0.89 (95% CI 0.65-1.21), respectively. CONCLUSION: We did not observe any increased risk of total bladder recurrence, BN/PU recurrence, or progression after a simultaneous endoscopic surgery of bladder tumour and BPH, as compared to TURBT alone.