首页良性前列腺增生治疗及预后证据详情

Assessment of the clinical efficacy of simultaneous transurethral resection of both bladder cancer and the prostate: a systematic review and meta-analysis

原文:2020年 发布于 Aging Male 23卷 第5期 1182-1193 浏览量:927次 原文链接

作者: Zhou L. Liang X. Zhang K.

作者单位: Department of Urology, Maoming People's Hospital, Maoming, China. Department of Dermatology, Maoming People's Hospital, Maoming, China.

归属分类: 良性前列腺增生治疗及预后证据

DOI: 10.1080/13685538.2020.1718637

关键词: Cystectomy Humans Male Prostate *Prostatic Hyperplasia/surgery *Transurethral Resection of Prostate Treatment Outcome *Urinary Bladder Neoplasms/surgery Bladder cancer benign prostatic hypertrophy prostate cancer transurethral resection

文献简介

OBJECTIVE: In this study, we aimed to examine the clinical efficacy of simultaneous transurethral resection of bladder cancer and the prostate (TURBT + TURP) in non-muscle invasive bladder cancer (NMIBC) and benign prostatic hyperplasia (BPH) patients. METHOD: We conducted systematic research in PubMed, EMBASE, and Cochrane Library databases to identify retrospective studies and prospective randomized controlled trials (RCTs) comparing patient outcomes between TURBT + TURP and TURBT-only patients. The meta-analysis was conducted using Review Manager 5.3. RESULTS: We identified eight relevant studies involving a total of 1032 patients. We found that patients that underwent TURBT + TURP exhibited significantly lower recurrence rates [odds ratio (OR), 0.70; 95% confidence interval (CI), 0.53-0.93; p = .01] and increased maximal urinary flow rate (Qmax) (WMD, 5.92; 95% CI, 4.67-7.16; p < .001) compared with patients that underwent TURBT-only. However, rates of recurrence at the prostatic urethra/bladder neck and bladder tumor progression, as well as the time to recurrence did not differ significantly between these two groups. CONCLUSIONS: Simultaneous TURBT + TURP can be safely performed in patients with NMIBC and BPH and improves patient quality of life, without any risk of increasing tumor recurrence or metastasis rates. Comprehensive RCTs are needed to confirm the results of this study.

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