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Association between benign prostate hyperplasia and metabolic syndrome in men under 60 years old: a meta-analysis

原文:2019年 发布于 Journal of International Medical Research 47卷 第11期 5389-5399 浏览量:721次 原文链接
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Objective To assess the potential relationship between benign prostate hyperplasia (BPH) and metabolic syndrome in men under 60 years old. Methods We searched the Medline, Embase, and Web of Science databases for studies of patients with metabolic syndrome and BPH using the key words 'metabolic syndrome', 'benign prostatic hyperplasia', and 'BPH'. The odds ratios (ORs) and 95% confidence intervals (95%CIs) were extracted from the included studies and the role of metabolic syndrome in BPH and its characteristics (International Prostate Symptom Score (IPSS), total prostate volume (TPV), postvoid residual (PVR)) were evaluated by meta-analysis. Results Six comparative studies comprising 61,826 individuals were identified and included in this meta-analysis. There were significant correlations between metabolic syndrome and BPH (OR = 1.24, 95%CI = 1.19-1.29), clinical BPH (OR = 1.37, 95%CI = 1.03-1.70), and TPV (OR = 2.34, 95%CI = 1.25-3.42). However, there was no significant association between metabolic syndrome and IPSS (OR = 1.19, 95%CI = 0.35-2.04) or PVR (OR = 2.15, 95% CI = 0.95-3.34). Conclusions These results indicate that metabolic syndrome is significantly and positively correlated with the incidence of BPH in younger men aged <60 years. However, there was no significant relationship between metabolic syndrome and BPH-related symptoms.

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