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The Efficacy and Safety of Urtica Dioica in Treating Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis

原文:2016年 发布于 African Journal of Traditional Complementary and Alternative Medicines 13卷 第2期 143-150 浏览量:998次 原文链接
文献简介

Background: Urtica dioica is extract from the root of a stinging nettle. Materials and Methods: We carried out a systematic review and meta-analysis to assess the efficacy and safety of Urtica dioica for treating Benign prostatic hyperplasia (BPH). A literature review was performed to identify all published randomized double-blind, controlled trials of Urtica dioica for the treatment of BPH. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated. Results: Five publications involving a total of 1128 patients were used in the analysis. Primary efficacy end points: the international prostate symptom score (IPSS) (the standardized mean difference (SMD) =-10.47, 95% confidence interval (CI) =-18.12 to -2.82, p= 0.007); the peak urinary flow rate (Qmax) (SMD= 4.37, 95% CI= 1.55 to 7.19, p= 0.002) and prostate volume (SMD=-3.63, 95% CI=-4.67 to -2.57, p< 0.00001) indicated that Urtica dioica was more effective than the placebo or controls. Safety assessments included prostatic specific antigen (PSA) (SMD=-0.08, 95% CI=-0.23 to 0.07, p= 0.31) showed that PSA levels were unaffected in both groups. Conclusion: This meta-analysis indicates that Urtica dioica to be an effective and safe treatment for LUTS associated with BPH.

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