首页膀胱肿瘤病因/危险因素证据详情

Intake of milk and other dairy products and the risk of bladder cancer: a pooled analysis of 13 cohort studies

原文: 2020 年 发布于 Int J Surg 5 卷 第 10 期 573-579 浏览量:271次

作者: Acham M. Wesselius A. van Osch F. H. M. Yu E. Y. van den Brandt P. A. White E. Adami H. O. Weiderpass E. Brinkman M. Giles G. G. Milne R. L. Zeegers M. P.

作者单位: Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy. Electronic address: stracciapatrizia@libero.it. Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy. Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy Università Cattolica del Sacro Cuore, Rome, Italy.

归属分类: 膀胱肿瘤病因/危险因素证据

DOI: 10.3389/fimmu.2022.986911

关键词: Cystectomy/*adverse effects Humans Lymphatic Metastasis Neoplasm Invasiveness Neoplasm Recurrence Local/etiology/*pathology Urinary Bladder Neoplasms/pathology/*surgery Vascular Neoplasms/etiology/*pathology Bladder cancer Lymph node dissection Lymphovascular invasion Meta-analysis Metastasis Radical cystectomy

文献简介

BACKGROUND: Pelvic lymphadenectomy (PLND) is an integral part of curative surgery for high-risk non-muscle invasive and muscle-invasive bladder cancer. The therapeutic value of extended PLND is controversial. METHODS: We conducted a comprehensive online search in PubMed, EMBASE, and the Cochrane Library databases for relevant literature directly comparing extended PLND (e-PLND) with non-extended PLND (ne-PLND) from database inception to June 2019. We performed the meta-analysis to evaluate the impact of PLND templates on recurrence-free survival (RFS), disease-specific survival (DSS), overall survival (OS), rates of postoperative major complications, and mortality within 90 days of surgery. RESULTS: A total of 10 studies involving 3979 patients undergoing either e-PLND or ne-PLND were included. The results showed that e-PLND was significantly associated with better RFS (HR 0.74, 95% CI 0.62-0.90, p = 0.002) and DSS (HR 0.66, 95% CI 0.55-0.79, p < 0.001). However, no correlation was found between e-PLND template and a better OS (HR 0.93, 95% CI 0.55-1.58, p = 0.79). Postoperative major complications were similar between e-PLND group and ne-PLND group, as was mortality within 90 days of surgery. CONCLUSION: e-PLND template is correlated with favorable RFS and DSS outcomes for patients with bladder cancer. e-PLND did not have more postoperative major complications than did ne-PLND.

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