首页膀胱肿瘤病因/危险因素证据详情

Histopathological and prognostic significance of the expression of sex hormone receptors in bladder cancer: A meta-analysis of immunohistochemical studies

原文: 2017 年 发布于 J Endourol 浏览量:228次

作者: Ide H. Inoue S. Miyamoto H.

作者单位: Clinica Luganese Moncucco, Lugano, Switzerland Clinica S. Anna, Swiss Medical Group, Sorengo, Switzerland Clinica Santa Chiara, Locarno, Switzerland Department of Urology, Luzerner Kantonsspital, Spitalstrasse, 6000 Luzern, Switzerland. Electronic address: roberto.carando@bluewin.ch. Department of Urology, Centre Hospitalier Universitaire Tours, Tours, France Department of Urology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria. Department of Urology, Luzerner Kantonsspital, Spitalstrasse, 6000 Luzern, Switzerland. Division of Urology, Department of Surgical Sciences, University of Studies of Torino, Turin, Italy. Department of Urology, University Medical Center Rostock, Rostock, Germany. Department of Urology, Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany. Department of Urology and Oncologic Urology, Wrocław Medical University, Wroclaw, Poland. Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. Department of Urology, University `Aldo Moro`, Bari, Italy. Department of Urology Bichat Hospital, Paris Descartes University, Paris, France.

归属分类: 膀胱肿瘤病因/危险因素证据

DOI: 10.1016/j.urolonc.2020.11.037

文献简介

Background: The role of the IGF axis in bladder cancer has been extensively studied in recent years, but the results are controversial. Methods: Pubmed, Embase, China national knowledge infrastructure and Wanfang databases were searched to identify eligible studies to evaluate the association among IGF-1, IGFBP-3, IGF-1R and IMP-3 expression and bladder cancer risk, depth of invasion and recurrence. Results: 15 studies were involved in the analysis, 5 of them reported the relation between serum concentration of IGF-1 or IGFBP-3 and bladder cancer risk. The difference in serum IGF-1 concentration was not significant between patients with bladder cancer and health controls (P=0.57). The serum IGFBP-3 concentration was lower in patients with bladder cancer (SMD: -0.78, 95% CI: -1.40, -0.15). 10 studies were involved in the analysis of the relation between IGF-1R or IMP-3 expression and bladder cancer. The expressions of IGF-1R and IMP-3 were elevated in MIBC compared with NMIBC (OR: 0.30, 95% CI: 0.19, 0.48 and OR: 0.30, 95% CI: 0.19, 0.46). The expressions of IGF-1R and IMP-3 were also found to be elevated in recurrent bladder cancer compared with primary bladder cancer (OR: 5.05, 95% CI: 2.43, 10.51 and OR: 2.47, 95% CI 1.48, 4.13). Conclusion: The IGF axis plays an important role in tumor proliferation and invasion, recurrence and metastasis. IGFBP-3 may be a potential serum biomarker for the screening of bladder cancer. The elevated expressions of IGF-1R and IMP3 in tissue are symbols of a highly malignant bladder cancer, and they could be utilized in the molecular classification of bladder. IGF-1R may be a promising therapeutic target for bladder cancer, but further studies are needed to evaluate the sensitivity of bladder cancer to the new targeted drugs and the predictive effect of serum IGFs in the targeted therapy.

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