首页膀胱肿瘤病因/危险因素证据详情

同期经尿道电切治疗膀胱癌及前列腺增生可行性的 Meta 分析

原文: 2018 年 发布于 Eur Urol Focus 11 卷 第 3 期 3246-3258 浏览量:225次

作者: 余登祥

作者单位: Department of Urology, Tianjin First Central Hospital, Nankai University, Tianjin, China. Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

归属分类: 膀胱肿瘤病因/危险因素证据

DOI: 10.4103/jcrt.JCRT_539_20

关键词: Biomarkers Tumor/genetics DNA Methylation Epigenesis Genetic *Gene Expression Regulation Neoplastic Humans Prognosis Retrospective Studies Urinary Bladder Neoplasms/*genetics Chromatin remodeling Methylation Non-coding RNA Progression Recurrence Urothelial carcinoma

文献简介

BackgroundRobot-assisted radical cystectomy (RARC) is increasing annually for treatment of bladder cancer. The objective of this meta-analysis was to compare the safety and efficacy of RARC and open radical cystectomy (ORC) for bladder cancer. MethodsOur meta-analysis searches were conducted using PubMed, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCT) assessing the two techniques. ResultsFour RCT studies were identified, including 239 cases. Our studies indicated that RARC was associated with longer operative time (WMD: 69.69, 95% CI:17.25 to122.12; P= 0.009), lower estimated blood loss (WMD: -299.83, 95% CI:-414.66to -184.99; P<0.00001). The two groups had no significant difference in overall perioperative complications, length of hospital stay, lymph node yield and positive surgical margins. ConclusionsRARC is mini-invasive alternative to ORC for bladder cancer. The advantage of RARC was reduced estimated blood loss. More studies are needed to compare the two techniques.

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