Impact of Smoking Habit on Perioperative Morbidity in Patients Treated with Radical Cystectomy for Urothelial Bladder Cancer: A Systematic Review and Meta-analysis
原文： 2021 年 发布于
Prog Urol
39 卷 第 6 期 Cd009294
浏览量：186次
作者：
Tellini R.
Mari A.
Muto G.
Cacciamani G. E.
Ferro M.
Stangl-Kremser J.
Campi R.
Soria F.
Rink M.
Xylinas E.
Minervini A.
Briganti A.
Montorsi F.
Roupret M.
Shariat S. F.
Moschini M.
作者单位：
Division of Cancer Sciences, University of Manchester, Manchester, UK
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK. Electronic address: ananya.choudhury@nhs.net. Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK. Division of Cancer Sciences, University of Manchester, Manchester, UK
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK. Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK. Division of Cancer Sciences, University of Manchester, Manchester, UK
Department of Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK. Division of Cancer Sciences, University of Manchester, Manchester, UK. Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. Radiotherapy and Imaging Division, The Institute of Cancer Research, London, UK
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Radiotherapy and Imaging Division, The Institute of Cancer Research, London, UK
Royal Marsden NHS Foundation Trust, London, UK. Division of Cancer Sciences, University of Manchester, Manchester, UK
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK
Mount Vernon Cancer Centre, Northwood, UK.
归属分类：
膀胱肿瘤病因/危险因素证据
DOI：
10.21037/tau-20-1363
关键词：
Metabolic syndrome (MS)
bladder cancer (BC)
grade
meta-analysis
stage
form (available at http://dx.doi.org/10.21037/tcr-20-3350). The authors have no
conflicts of interest to declare.
Despite early detection and regular surveillance of non-muscle invasive bladder cancer (NMIBC), recurrence and progression rates remain exceedingly high for this highly prevalent malignancy. Limited visualization of malignant lesions with standard cystoscopy and associated false-negative biopsy rates have been the driving force for investigating alternative and adjunctive technologies for improved cystoscopy. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Out of 1,087 studies reviewed, 17 prospective non-randomized and randomized controlled trials met inclusion criteria for the study. We demonstrated that tumor resection with either PDD and NBI exhibited lower recurrence rates and greater diagnostic sensitivity compared to WLC alone. NBI demonstrated superior disease sensitivity and specificity as compared to WLC and an overall greater hierarchical summary receiver operative characteristic. Our findings are consistent with emerging guidelines and underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC.