首页膀胱肿瘤病因/危险因素证据详情

Perioperative nutrition for the treatment of bladder cancer by radical cystectomy

原文: 2019 年 发布于 Front Physiol 42 卷 第 6 期 153-154 浏览量:198次
文献简介

Introduction Bladder cancer (BC) is one of the most common urologic malignancies and it is urgently needed to identify novel potential prognostic biomarkers for predicting prognosis and progression of patients with BC in clinical practice. Previous research has revealed that long noncoding RNAs (IncRNAs) played critical roles in BC, and may serve as novel potential prognostic biomarkers in patients with BC. Therefore, we conducted this meta-analysis to clarify the prognostic potential of IncRNAs in BC patients. Methods A comprehensive search was performed in PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). According to the predefined exclusion and inclusion criteria, a total of 9 recently published articles comprising 13 IncRNAs and 666 BC patients were included into this meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between IncRNAs expression and survival outcomes. We also analyzed the odds ratio (ORs) and 95% confidence intervals (CIs) to assess the association between IncRNAs expression and clinicopathological characteristics, including histological grade, gender, multifocality, tumor size, and tumor stage. Results Our results revealed that high IncRNAs expression was associated with shorter overall survival in Asian BC patients (pooled HR = 2.32, 95% CI: 1.35-4.00, P= 0.002, random-effect). High IncRNAs expression levels were significantly associated with histological grade (G2-G3 vs. G1: OR = 3.857, 95%CI: 1.293-11.502, P= 0.015, random-effect). Conclusions In summary, this meta-analysis has demonstrated that IncRNAs could be used as potential prognostic markers for BC and high IncRNAs expression could predict poor prognosis among Asian BC patients.

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