首页膀胱肿瘤病因/危险因素证据详情

Dietary consumption of cruciferous vegetables and bladder cancer risk: A systematic review and meta-analysis

原文: 2022 年 发布于 Int J Clin Oncol 191 卷 第 17 期 739-748 浏览量:214次
文献简介

OBJECTIVE: Previous studies on the association of cruciferous vegetables intake with bladder cancer risk have reported inconsistent results. We performed the present meta-analysis to summarize evidence on this association and to quantify the potential dose-response relation based on all available cohort studies. METHODS: A comprehensive literature search of relevant articles up to March 2022 was performed in PubMed and EMBASE. The summary risk estimates with 95% confidence intervals for the highest vs. the lowest intake of cruciferous vegetables were calculated. Dose-response meta-analysis was also performed for studies reporting categorical risk estimates for at least three quantitative levels of cruciferous vegetables intake. RESULTS: We found that the highest cruciferous vegetables intake was not significantly associated with a lower risk of bladder cancer, compared with the lowest cruciferous vegetables intake category (RR = 0.92, 95% CI 0.80-1.06). Linear dose-response meta-analysis indicated that the pooled RRs for 10 g/day or 1 servings/week increment of cruciferous vegetables intake was not significantly associated with a reduced risk of bladder cancer (P = 0.106 and P = 0.147, respectively). There was no evidence of significant publication bias either with Begg's test (P = 0.386) or Egger's test (P = 0.253). CONCLUSION: The results of this study did not support the hypothesis that dietary cruciferous vegetables intake was associated with a lower risk of bladder cancer. Further large prospective cohort studies are warranted to confirm our preliminary findings.

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