Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk
原文： 2020 年 发布于
World J Urol
38 卷 第 09 期 131-144
浏览量：215次
作者：
Zhu H.
Mo Q.
Shen H.
Wang S.
Liu B.
Xu X.
作者单位：
Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. Department of Cell and Molecular Biology, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures, Romania. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Department of Urology, University of Bern, Bern, Switzerland. Department of Urology, Jikei University School of Medicine, Tokyo, Japan. Department of Urology, Rennes University Hospital, Rennes, France. Division of Urology, European Institute of Oncology, Milan, Italy. Department of Urology, Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. shahrokh.shariat@meduniwien.ac.at. Department of Urology, Weill Cornell Medical College, New York, NY, USA. shahrokh.shariat@meduniwien.ac.at. Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. shahrokh.shariat@meduniwien.ac.at. Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. shahrokh.shariat@meduniwien.ac.at. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. shahrokh.shariat@meduniwien.ac.at.
归属分类：
膀胱肿瘤病因/危险因素证据
DOI：
10.1159/000506655
关键词：
Anastomosis
Surgical/adverse effects/instrumentation/methods
Constriction
Pathologic/etiology
Cystectomy/*instrumentation/methods
Humans
Ileum/surgery
Incidence
Postoperative Complications/etiology
Stents/*adverse effects
Ureter/surgery
Ureteral Obstruction/*etiology
Urinary Bladder Neoplasms/surgery
Urinary Catheters/adverse effects
Urinary Diversion/adverse effects/*instrumentation/methods
Cystectomy
Internal double-J stent
Orthotopic neobladder
Ureteroileal anastomosis stricture
Urinary diversion
Objective: To conduct a systematic review of whether blood transfusions may be associated with worse outcomes for patients with bladder cancer treated with radical cystectomy (RC), as there has been a recent increase in studies addressing this clinically relevant topic. Methods: PubMed, Ovid Medical Literature Analysis and Retrieval System Online (MEDLINE), Google Scholar, and the ClinicalTrials.gov databases were searched with pre-specified search terms for studies published between January 2010 and May 2020. The systemic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of 17 studies with 19 627 patients were included after 183 records were screened for eligibility. In all, 10 studies proposed perioperative blood transfusion to be associated with impaired prognosis regarding overall survival, nine studies regarding cancer-specific and four studies regarding recurrence-free survival. The timing of blood transfusion might affect patient outcomes. Notably, several studies did not find a significant correlation between blood transfusions and prognosis. As all studies to date are of retrospective design, the grade of evidence is still limited. Conclusions: Despite the lack of prospective trials, perioperative blood transfusion may lead to worse oncological outcomes. These results, as well as known non-oncological side-effects and associated costs, are important arguments to carefully consider the indication for blood transfusion. Abbreviations BCa: bladder cancer; CSS: cancer-specific survival; HR: hazard ratio; (N)MIBC: (non-) muscle-invasive BCa; OS: overall survival; PBT, perioperative blood transfusion; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RC: radical cystectomy; RFS: recurrence-free survival.