首页膀胱肿瘤病因/危险因素证据详情

Dietary N-nitroso compounds intake and bladder cancer risk: A systematic review and meta-analysis

原文: 2021 年 发布于 Cancer Treat Res Commun 8 卷 第 11 期 731318 浏览量:212次

作者: SeyyedSalehi M. S. Mohebbi E. Sasanfar B. Toorang F. Zendehdel K.

作者单位: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, Chengdu, Sichuan, 610041, China. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, Chengdu, Sichuan, 610041, China. hanpingwch@163.com.

归属分类: 膀胱肿瘤病因/危险因素证据

DOI: 10.1371/journal.pone.0198602

关键词: Disease-Free Survival *Dose Fractionation Radiation Humans Neoplasm Recurrence Local/epidemiology/pathology/*radiotherapy Radiation Dose Hypofractionation/*standards Risk Factors Treatment Outcome Urinary Bladder Neoplasms/epidemiology/pathology/*radiotherapy

文献简介

PURPOSE: To investigate the impact of preoperative nutritional factors [body mass index (BMI)], hypoalbuminemia (< 3.5 g/dL, sarcopenia) on complication and mortality rates after radical cystectomy (RC) for bladder cancer. METHODS: The PubMed database was systematically searched for studies investigating the effect of nutritional status on postoperative outcomes after RC. English-language articles published between March 2010 and March 2020 were reviewed. For statistical analyses odds ratios (ORs) and hazard ratios (HRs) weighted mean was applied. RESULTS: Overall, 81 studies were included. Twenty-nine studies were enrolled in the final analyses. Patients with a 25-29.9 kg/m(2) BMI (OR 1.55, 95% confidence interval [CI] 1.14-2.07) and those with a BMI ≥ 30 kg/m(2) (OR 1.73, 95% CI 1.29-2.40) had a significantly increased risk of 30 day complications after RC. Preoperative hypoalbuminemia increased the risk of 30 day complications (OR 1.56, 95% CI 1.07-2.35); it was a predictor of worse 3 year overall survival (OS) (HR 1.86, 95% CI 1.32-2.66). Sarcopenic patients had a higher risk of 90 day complications than non-sarcopenic ones (OR 2.49, 95% CI 1.22-5.04). Sarcopenia was significantly associated with unfavorable 5 year cancer-specific survival (CSS) (HR 1.73, 95% CI 1.07-2.80), and OS (HR 1.60, 95% CI 1.13-2.25). CONCLUSION: High BMI, hypoalbuminemia, and sarcopenia significantly increased the complication rate after RC. Hypoalbuminemia predicted worse 3 year OS and sarcopenia predicted unfavorable 5 year CSS and OS. Preoperative assessment of RC patients' nutritional status is a useful tool to predict perioperative and survival outcomes.

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