首页膀胱肿瘤诊断证据详情

膀胱癌根治术淋巴结阳性、清扫数量对预后影响的系统评价

原文: 2017 年 发布于 Oncotarget 浏览量:181次

作者: 凌枫盛

作者单位: Department of Urology, University Medical Center Goettingen, Goettingen, Germany. Electronic address: annemarie.uhlig@med.uni-goettingen.de. Department of Urology, University Medical Center Goettingen, Goettingen, Germany. Department of Radiology, University Medical Center Goettingen, Goettingen, Germany. Department of Radiology, University Medical Center Goettingen, Goettingen, Germany Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.

归属分类: 膀胱肿瘤诊断证据

DOI: 10.23736/S0393-2249.20.03680-2

文献简介

BACKGROUND: A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. METHODS: EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. `rs798766` and `urinary bladder cancer` were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated. RESULTS: We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] OR = 1.27, 95%CI = 1.20-1.33. Subgroup analysis by ethnicity revealed similar results, allelic[T] OR = 1.24, 95%CI = 1.17-1.32 in Caucasian subjects and allelic[T] OR = 1.33, 95%CI = 1.21-1.46 in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians. CONCLUSION: rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.

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