首页膀胱肿瘤治疗及预后证据详情

Prognostic blood-based biomarkers in patients treated with neoadjuvant chemotherapy for urothelial carcinoma of the bladder: A systematic review

原文: 2021 年 发布于 Semin Oncol Nurs 10 卷 第 3 期 810-823 浏览量:180次

作者: Laukhtina E. Pradere B. Mori K. Schuettfort V. M. Quhal F. Mostafaei H. Sari Motlagh R. Aydh A. Moschini M. Enikeev D. Karakiewicz P. I. Abufaraj M. Shariat S. F.

作者单位: Department of Urology, Turku University Hospital, Turku, Finland. Department of Urology, Aarhus University Hospital, Aarhus, Denmark. School of Medical Sciences, Faculty of Medicine and Health, University of Örebro, Örebro, Sweden. Norwegian University of Science and Technology, Trondheim, Norway. Department of Urology, Landspitali University Hospital, Reykjavik, Iceland.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1371/journal.pone.0243136

关键词: Cancer-specific survival Cystectomy T1G3 bladder cancer

文献简介

AIM: The study retrospectively analysed the accuracy of preoperative contrast-enhanced ultrasound (CEUS) in differenti-ating stage Ta-T1 or low-grade bladder cancer (BC) from stage T2 or high-grade bladder cancer. MATERIAL AND METHODS: We systematically searched the literature indexed in PubMed, Embase, and the Cochrane Library for original diagnostic articles of bladder cancer. The diagnostic accuracy of CEUS was compared with cystoscopy and/or transurethral resection of bladder tumors (TURBT). The bivariate logistic regression model was used for data pooling, couple forest plot, diagnostic odds ratio (DOR) and summary receiver operating characteristic (SROC). RESULTS: Five studies met the selection criteria; the overall number of reported bladder cancers patients were 436. The pooled-sensitivity (P-SEN), pooled-specificity (P-SPE), pooled-positive likelihood ratio (PLR+), pooled-negative likelihood ratio (PLR-), DOR, and area under the SROC curve were 94.0% (95%CI: 85%-98%), 90% (95%CI: 83%-95%), 9.5 (95%CI: 5.1-17.6), 0.06 (95%CI: 0.02-0.17), 147 (95%CI: 35-612) and 97% (95% CI: 95%-98%) respectively. CONCLUSION: CEUS reaches a high efficiency in discriminating Ta-T1 or low-grade bladder cancer from stage T2 or high-grade bladder cancer. It can be a promising method in patients to distinguish T staging and grading of bladder cancer because of its high sensitivity, specificity and diagnostic accuracy.

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