Background: Assessing the prognostic significance of specific clinicopathological features plays an important role in surgical management after radical cystectomy. This study investigated the association between ten clinicopathological characteristics and cancer-specific survival (CSS) in patients with bladder cancer. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, a literature search was conducted through the PubMed, EMBASE and Web of Science databases using appropriate search terms from the dates of inception until November 2018. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the CSS. Fixed- or random-effects models were constructed according to existence of heterogeneity. Results: Thirty-three articles met the eligibility criteria for this systematic review, which included 19,702 patients. The overall results revealed that CSS was associated with advanced age (old vs. young: pooled HR=1.01; 95% CI:1.00-1.01; P<0.001), higher tumor grade (3 vs. 1/2: pooled HR=1.29; 95% CI:1.15-1.45; P<0.001), higher pathological stage (3/4 vs. 1/2: pooled HR=1.60; 95% CI:1.37-1.86; P<0.001), lymph node metastasis (positive vs. negative: pooled HR=1.51; 95% CI:1.37-1.67; P<0.001), lymphovascular invasion (positive vs. negative: pooled HR=1.36; 95% CI:1.28-1.45; P<0.001), and soft tissue surgical margin (positive vs. negative: pooled HR=1.42; 95% CI:1.30-1.56; P<0.001). However, gender (male vs. female: pooled HR=0.98; 95% CI: 0.96-1.01; P=0.278), carcinoma in situ (positive vs. negative: pooled HR=0.98; 95% CI: 0.88-1.10; P=0.753), histology (transitional cell cancer vs variant: pooled HR=0.90; 95% CI: 0.79-1.02; P=0.089) and adjuvant chemotherapy (yes vs. no: pooled HR=1.16; 95% CI: 1.00-1.34; P=0.054) did not affect CSS after radical resection of bladder cancer. Conclusions: Our results revealed that several clinicopathological characteristics can predict CSS risk after radical cystectomy. Prospective studies are needed to further confirm the predictive value of these variables for the prognosis of bladder cancer patients after radical cystectomy.