首页膀胱肿瘤治疗及预后证据详情

Patient-reported outcomes in non-muscle invasive bladder cancer: a mixed-methods systematic review

原文: 2021 年 发布于 Transl Androl Urol 73 卷 第 1 期 1207-1213 浏览量:215次

作者: Rutherford C. Patel M. I. Tait M. A. Smith D. P. Costa D. S. J. Sengupta S. King M. T.

作者单位: Translational Oncology and Urology Research, King's College London, London, UK. Urology Department, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Guy's Cancer, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.3389/fsurg.2021.636791

关键词: Biomarkers Tumor/*metabolism Estrogen Receptor alpha/*metabolism Estrogen Receptor beta/*metabolism GATA3 Transcription Factor/*metabolism Humans Prognosis Urinary Bladder Neoplasms/diagnosis/*metabolism Gata3 bladder cancer estrogen receptors immunohistochemistry tumour markers commercial or financial relationships that could be construed as a potential conflict of interest.

文献简介

Background: Bipolar and monopolar transurethral resections have a stable status for non-muscle invasive bladder cancer (NMIBC). We conducted a meta-analysis to analyze the outcomes and complications of bipolar vs. monopolar energy for transurethral resection of bladder tumors (TURB). Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses was followed. Based on the Population, Intervention, Comparator, Outcomes, and Study Designs (PICOS) strategy, randomized controlled trials were searched in MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the associated articles were also retrieved. The data were calculated by Rev Man v5.3.0. Results: Eleven publications containing an amount of 2, 099 patients were involved in the study. Two groups did not show a significant difference in the mean age and the number of bladder tumors. The results showed that m-TURB had a greater decrease in postoperative hemoglobin level [mean difference (MD) -0.26, 95% confidence interval (CI) -0.48 to -0.04, P = 0.02] and sodium level (MD -0.36, 95% CI -0.62 to -0.10, P = 0.007) compared with b-TURB. B-TURB spent relatively little in hospitalization time (MD -0.52, 95% CI -0.88 to -0.15, P = 0.005) than m-TURB with the exception of operation time (P = 0.47) and catheterization time (P = 0.19). B-TURB did not show a significant difference in the incidence rate of obturator reflex (P = 0.10), bladder perforation (P = 0.32), postoperative blood transfusion (P = 0.28), and clot retention (P = 0.21) compared with the b-TURB group. Besides, there were no significant difference in terms of muscle tissue sampling (P = 0.43), recurrence-free survival at 6 months (P = 0.68) and 12 months (P = 0.78). Conclusions: B-TURB was more effective than m-TURB in minimizing intraoperative or postoperative bleeding with the smaller loss of hemoglobin and the shorter hospitalization time for patients with NMIBC.

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