经尿道激光与传统电切术治疗非肌层浸润性膀胱肿瘤安全性及疗效的 meta 分析

原文： 2017 年发布于 World J Surg Oncol  浏览量：164次 原文链接

作者单位： UroEvidence@Deutsche Gesellschaft für Urologie, Martin-Buber-Str. 10, Berlin, Germany, 14163. University Hospital Erlangen, Department of Urology, Krankenhausstrasse 12, Erlangen, Germany, 91054. Cardiff University Library Services, Velindre NHS Trust, Velindre Cancer Centre, Whitchurch, Cardiff, UK, CF14 2TL. University of Rostock, Department of Urology, Ernst-Heydemann-Strasse 7, Rostock, Mecklenburg-Vorpommern, Germany, 18057. University of Muenster Medical Center, Department of Urology, Albert-Schweitzer Campus 1, GB A1, Muenster, NRW, Germany, 48149. Medical Center - University of Freiburg, Department of Neurology and Neurophysiology, Berliner Allee 29, Freiburg, Germany, 79110. University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany. Minneapolis VA Health Care System, Urology Section, One Veterans Drive, Mail Code 112D, Minneapolis, Minnesota, USA, 55417. University of Minnesota, Department of Urology, 420 Delaware Street SE, MMC 394, Minneapolis, Minnesota, USA, 55455. Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Institute for Evidence in Medicine, Breisacher Str. 153, Freiburg, Germany, D-79110.

归属分类：膀胱肿瘤治疗及预后证据

DOI： 10.1016/j.urolonc.2021.01.025

BACKGROUND: Previous studies have revealed the importance of microRNAs' (miRNAs) function as biomarkers in diagnosing human bladder cancer (BC). However, the results are discordant. Consequently, the possibility of miRNAs to be BC biomarkers was summarized in this meta-analysis. METHODS: In this study, the relevant articles were systematically searched from CBM, PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI). The bivariate model was used to calculate the pooled diagnostic parameters and summary receiver operator characteristic (SROC) curve in this meta-analysis, thereby estimating the whole predictive performance. STATA software was used during the whole analysis. RESULTS: Thirty-one studies from 10 articles, including 1556 cases and 1347 controls, were explored in this meta-analysis. In short, the pooled sensitivity, area under the SROC curve, specificity, positive likelihood ratio, diagnostic odds ratio, and negative likelihood ratio were 0.72 (95%CI 0.66-0.76), 0.80 (0.77-0.84), 0.76 (0.71-0.81), 3.0 (2.4-3.8), 8 (5.0-12.0), and 0.37 (0.30-0.46) respectively. Additionally, sub-group and meta-regression analyses revealed that there were significant differences between ethnicity, miRNA profiling, and specimen sub-groups. These results suggested that Asian population-based studies, multiple-miRNA profiling, and blood-based assays might yield a higher diagnostic accuracy than their counterparts. CONCLUSIONS: This meta-analysis demonstrated that miRNAs, particularly multiple miRNAs in the blood, might be novel, useful biomarkers with relatively high sensitivity and specificity and can be used for the diagnosis of BC. However, further prospective studies with more samples should be performed for further validation.