首页膀胱肿瘤治疗及预后证据详情

Neoadjuvant Chemotherapy for Different Stages of Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-analysis

原文: 2022 年 发布于 Crit Rev Oncol Hematol 17 卷 第 4 期 39-46 浏览量:243次

作者: Liu S. Yao Y. Guan F. Sun L. Zhang G.

作者单位: Department of Hematology and Oncology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA. Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA. Department of Urology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA jdrabick@hmc.psu.edu. Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Department of Hematology and Oncology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA jdrabick@hmc.psu.edu.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1177/0269215517746472

关键词: Bayes Theorem Cystectomy Humans *Laparoscopy Postoperative Complications/surgery *Robotic Surgical Procedures *Robotics Treatment Outcome *Urinary Bladder Neoplasms/surgery

文献简介

BACKGROUND: Systemic immune-inflammation index (SII) has recently emerged as a biomarker for the prognosis of a variety of malignant tumors. However, the role of SII in bladder cancer (BC) remains unclear. To this end, we performed a pooled analysis to investigate the prognostic value of preoperative SII in patients with BC. METHODS: A comprehensive search of electronic databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) was conducted to determine the eligible studies that were published until January 2022. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between preoperative SII and the prognosis and clinicopathological characteristics of BC. RESULTS: Ten studies with 7,087 patients were included in this analysis. SII was observed to be correlated with inferior overall survival (HR = 1.22, 95% CI 1.04-1.44, p = 0.013), cancer-specific survival (HR = 1.68, 95% CI 1.14-2.47, p = 0.009), and recurrence-free survival (HR = 1.29, 95% CI 1.03-1.61, p = 0.027). An increased preoperative SII was also associated with poor tumor differentiation, higher tumor stage, presence of lymph node involvement, and tumor size ≥3 cm (all p < 0.05). CONCLUSIONS: An elevated preoperative SII is significantly associated with worse survival outcomes and adverse pathological features in patients with BC. Hence, SII may serve as a strong independent prognostic predictor for patients with BC after surgery.

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