Adjuvant chemotherapy in patients with locally advanced bladder cancer after neoadjuvant chemotherapy and radical cystectomy: a systematic review and pooled analysis
原文： 2021 年 发布于
现代泌尿外科杂志
30 卷 第 1 期 78-87
浏览量：262次
作者：
Cai Z. Y.
Jin H.
Chen J. B.
Hu J.
Li H. H.
Yi Z. L.
Zu X. B.
作者单位：
Department of Urology, Medical University of Vienna, Vienna, Austria. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan. Department of Urology, Ehime University Graduate School of Medicine, Ehime, Japan. King Fahad Specialist Hospital, Dammam, Saudi Arabia. King Faisal Medical City, Abha, Saudi Arabia. Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia. Department of Urology, University Hospital of Tours, Tours, France. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada. Department of Urology, University Hospital Frankfurt, Frankfurt am Main, Germany. Department of Urology, Weil Cornell Medical College, New York, NY, USA. Department of Urology, University of Texas Southwestern, Dallas, TX, USA. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan. European Association of Urology Research Foundation, Arnhem, The Netherlands.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.3233/BLC-201511
关键词：
Anti-Bacterial Agents/therapeutic use
Antibiotic Prophylaxis
Humans
Meta-Analysis as Topic
Postoperative Complications/drug therapy
Systematic Reviews as Topic
*Urinary Bladder Neoplasms/drug therapy/surgery
*Urinary Tract Infections/drug therapy/prevention & control
Antibiotic resistance
Antibiotics
Antimicrobial stewardship
Bacteriuria
Endourological surgery
Guideline
Recommendation
Transitional cell carcinoma
Urothelium cell carcinoma
BACKGROUND: This study will systematically assess the efficacy and safety of Bacillus Calmette-Guerin (BCG) for patients with bladder cancer (BC). METHODS: Literature searches will be performed in multiple electronic databases from inception to present: MEDLINE, EMBASE, CINAHL, Science Direct, Cochrane Library, Web of Science, and China National Knowledge Infrastructure. We will also examine grey literature through identifying conference proceedings, thesis, dissertations, and website of clinical trials registry. Two investigators will independently scan all citation titles, abstracts, and full-text studies. The study quality will be assessed by Cochrane Risk of Bias Tool. If possible, we will perform meta-analysis. Additional analyses will be carried out to test the potential sources of heterogeneity among included trials. RESULTS: The present study will summarize high quality trials on investigating the efficacy and safety of BCG for patients with BC. CONCLUSION: The results of this study will supply helpful evidence to determine whether BCG is effective or not for BC. STUDY REGISTRATION NUMBER: INPLASY202070042.