Curative Effect and Survival Assessment Comparing Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin and Cisplatin as Neoadjuvant Therapy for Bladder Cancer: A Systematic Review and Meta-Analysis
原文： 2021 年 发布于
World J Urol
10 卷 第 6 期 426-433
浏览量：227次
作者：
Wu T. E.
Wu Y. Q.
Chen S. Q.
Wu J. P.
Zhu W. D.
Liu H.
Chen M.
Xu B.
作者单位：
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Department of Urology, University of Florence, Careggi Hospital, Florence, Italy. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Department of Urology, Jikei University School of Medicine, Tokyo, Japan. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Department of Urology, Kantonsspital Winterthur, Winterthur, Switzerland. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Department of Special Surgery, Jordan University hospital, The University of Jordan, Amman, Jordan. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX
Department of Urology, Weill Cornell Medical College, New York, NY. Electronic address: shahrokh.shariat@meduniwien.ac.at.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.16016/j.1000-5404.201901104
关键词：
Humans
Quality of Life
Retrospective Studies
*Sarcopenia/epidemiology/etiology
*Urinary Bladder Neoplasms/complications/epidemiology
Bladder cancer
Prevalence
Sarcopenia
Systematic review
Bladder cancer is the most common cancer of the urinary tract. While tobacco smoking is responsible for more than half of the bladder cancer cases, occupational exposures is also an established risk factor of bladder cancer. Strong evidence of carcinogenicity of N-nitroso compounds (NOCs) have been provided in animal and human studies, but the target organ of occurring cancer in human including bladder cancer is still obscure. A wide range of NOCs sources surrounded us like diet, drinking water, cigarette smoking, workplace, and indoor air population. We conducted a meta-analysis to elucidate the association between NOCs in drinking water and food source and bladder cancer risk. Ten articles were included after removing the duplicates and irrelevant articles. The majority studies of our meta-analysis was done on women, maybe because of cigarette smoking as a main risk factor among men which is more common among men than women. Although the number of articles was limited our meta-analysis showed no significant association between dietary intakes of NOCs and bladder cancer risk (OR = 0.96, 95% CI = 0.88, 1.05; I2 = 50%, P-value = 0.007), neither subgrouping of NOCS type and source of NOCs nor dose of nitrate and nitrite intake indicated any associations.