Comparison of Pathological Outcome and Recurrence Rate between En Bloc Transurethral Resection of Bladder Tumor and Conventional Transurethral Resection: A Meta-Analysis
原文： 2023 年 发布于
Cancers (Basel)
47 卷 第 1 期 e28208
浏览量：277次
作者：
Wang C. W.
Lee P. J.
Wu C. W.
Ho C. H.
作者单位：
Department of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40 (Room C5.570), 6229 ER, Maastricht, The Netherlands. Department of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, Universiteitssingel 40 (Room C5.570), 6229 ER, Maastricht, The Netherlands. anke.wesselius@maastrichtuniversity.nl. Department of Clinical Studies and Nutritional Epidemiology, Nutrition Biomed Research Institute, Melbourne, Australia. Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Department of Epidemiology, Schools for Oncology and Developmental Biology and Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands. Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan. Fred Hutchinson Cancer Research Center, Seattle, WA, USA. International Agency for Research on Cancer World Health Organization, Lyon, France. CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. School of Cancer Sciences, University of Birmingham, Birmingham, UK.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.1038/s41598-021-90404-2
关键词：
Male
Humans
*Papillomavirus Infections/complications/epidemiology/prevention & control
Human Papillomavirus Viruses
Mendelian Randomization Analysis
Papillomaviridae/genetics
Human papillomavirus 18
*Urinary Bladder Neoplasms/epidemiology/complications
HPV prevalence
bladder cancer
human papillomavirus
mendelian randomization
meta-analysis
Current treatment for non-muscle invasive bladder cancer (NMIBC) is the conventional transurethral resection of bladder tumor (CTURBT), but the en bloc transurethral resection of bladder tumor (ERBT) has been gaining more attraction in recent years considering better specimen integrity. Thus, we conducted this meta-analysis to compare the safety and efficacy of ERBT versus CTURBT. Trials were collected from an online database. The primary outcomes included identification of detrusor muscle in specimen, residual tumor, 3, 12, and 24-month recurrence rates and same-site recurrence rate. A total of 31 trials were included. The ERBT group had a higher rate of identification of detrusor muscle in specimens (p = 0.003) and lower residual tumor (p < 0.001). Other than that, lower rates of 3-month (p = 0.005) and 24-month recurrence rate (p < 0.001), same-site recurrence rate (p < 0.001) and complications were also observed. For perioperative outcomes, shorter hospitalization time (HT) (p < 0.001), and catheterization time (CT) (p < 0.001) were also revealed in the ERBT group. No significant difference was found in operative time (OT) (p = 0.93). The use of ERBT showed better pathological outcomes and fewer complications, so it could be considered a more effective treatment option for NMIBC.