首页膀胱肿瘤治疗及预后证据详情

核基质蛋白 22 和膀胱肿瘤抗原对国人膀胱癌诊断价值的系统评价

原文: 2016 年 发布于 Cancer Research 浏览量:156次 原文链接

作者: 郝晓明 刘光明 徐子强 马洪顺 王伟 徐磊

作者单位: Clinical Research Development Unit of Imam Khomeini Hospital, Uremia University of Medical Sciences, Uremia, Iran. Department of General Surgery, Babol University of Medical Sciences, Mazandaran, Iran. Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Hasheminejad Kidney Center (HKC), Iran University of Medical Sciences, Tehran, Iran. Department of Urology, Alborz University of Medical Sciences, Karaj, Iran. Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1016/j.euf.2021.01.019

文献简介

Many studies reported the prognostic value of neutrophil to lymphocyte ratio (NLR) for bladder cancer, however, these studies presented conflicting results. In the present study, we intended to comprehensively investigate the associations between pretreatment NLR and overall survival (OS), cancer-specific survival (CSS)/disease-specific survival (DSS), and recurrence-free survival (RFS) through meta-analysis. The values of hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) from 9 studies with 2,300 patients were extracted and combined. The results suggested that increased NLR was correlated with shorten OS (HR=1.48, 95% CI=1.05-2.09, P=0.027) and CSS/DSS (HR=1.58, 95% CI=1.01-2.46, P=0.044), but had no correlation with RFS (HR=1.41, 95% CI=0.92-2.17, P=0.112). Furthermore, subgroup analyses stratified by different clinicopathological factors demonstrated that elevated NLR still predicted poor OS in large sample size studies and held prognostic value for RFS when NLR <= 2.5. In conclusion, the current study identifies NLR as a prognostic factor for poor OS and CSS/DSS, but not for RFS in bladder cancer.

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