Prognostic significance of systemic immune-inflammation index in patients with bladder cancer: A systematic review and meta-analysis
原文： 2022 年 发布于
Clin Nutr
26 卷 第 1 期 S1368-S1368
浏览量：161次
作者：
Cao W.
Shao Y.
Zou S.
Wang N.
Wang J.
作者单位：
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115. Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215. Division of Urologic Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA, 02115. Department of Pathology, Brigham and Women's Hospital, 45 Francis Street, Boston, MA, 02115. Harvard Medical School, 25 Shattuck Street, Boston, MA 02115
Division of Urologic Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA, 02115. Harvard Medical School, 25 Shattuck Street, Boston, MA 02115
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215
Division of Urologic Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA, 02115. Harvard Medical School, 25 Shattuck Street, Boston, MA 02115
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215
Division of Urologic Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA, 02115. Electronic address: mmossanen@bwh.harvard.edu.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.1002/bco2.65
关键词：
Cystectomy/*methods
Electrosurgery/*methods
Humans
Neoplasm Invasiveness
Treatment Outcome
Urethra
Urinary Bladder Neoplasms/pathology/*surgery
Bipolar
Meta-analysis
Monopolar
Transurethral bladder tumor resection
OBJECTIVE To assess the relationship of bladder cancer risk with eNOS G894T gene polymorphism using meta-analysis. METHOD The relevant articles were retrieved as of 30 August 2020 from PubMed and ScienceDirect. The associa-tions were estimated using the calculation of pooled odds ratio (OR) and 95% confidence interval (CIs). RESULTS Four studies, covering a total of 834 cases and 16,80 control subjects, regarding the eNOS G894T gene variant and the risk of bladder cancer were identified and used in our analysis. Our pooled calculation revealed no overall association between the risk of bladder cancer and eNOS G894T gene polymorphism in all genetic modes, including G allele (OR: 0.81 [95% CI: 0.63-1.05], p=0.11), T allele (OR: 1.23 [95% CI: 0.95-1.58], p=0.11), GG genotype (OR: 0.52 [95% CI: 0.25-1.06], p=0.07), GT genotype (OR: 1.59 [95% CI: 0.85-2.98], p=0.143), and TT genotype (OR: 1.15 [95% CI: 0.76-1.73], p=0,51). CONCLUSIONS Our meta-analysis revealed that the gene polymorphism of eNOS G894T does not affect the risk of bladder cancer.