首页膀胱肿瘤治疗及预后证据详情

Low serum 25-hydroxyvitamin D is associated with increased bladder cancer risk: A systematic review and evidence of a potential mechanism

原文: 2019 年 发布于 Clin Chim Acta 4 卷 第 1 期 61-68 浏览量:228次

作者: Dunn J. A. Jefferson K. MacDonald D. Iqbal G. Bland R.

作者单位: School of Cancer and Pharmaceutical Studies, Translational Oncology & Urology Research (TOUR), King's College London, London, United Kingdom. Department of Radiation Oncology, Ghent University, Ghent, Belgium. Dept. of Oncology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Bladder Cancer Research Centre, Institute of Cancer & Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Dept. of Psychology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. Department of Biobank Research, Umeå University, Umeå, Sweden.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1016/j.purol.2020.12.003

关键词: adaptive radiotherapy bladder cancer

文献简介

OBJECTIVE: The objective of this study was to perform a systematic review and meta-analysis to evaluate the two most commonly used chemotherapy regimens gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin/adriamycin, and cisplatin (MVAC) regimens for muscle-invasive bladder cancer (MIBC) patients. METHODS: We searched for all studies investigating GC and MVAC for MIBC patients in PubMed, Web of Knowledge, and the Cochrane Central Search Library. A systematic review and meta-analysis were performed. RESULTS: Our searches identified 13 studies among 2174 patients. In the meta-analysis, the pathological complete response to GC regimens was superior to MVAC regimens. No significant difference in pathological partial response was found between the two groups. GC regimens were associated with a significant decrease risk in Grade 3-4 neutropenia, mucositis, and febrile neutropenia, but a significant increase risk in Grade 3-4 thrombocytopenia. There was no significant difference in overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) when compared GC regimens to MVAC regimens. CONCLUSIONS: GC regimens significantly improved pathological complete response compared to MVAC regimens. GC regimens were associated with a significant decrease risk in Grade 3-4 neutropenia, mucositis, and febrile neutropenia, but a significant increase risk in Grade 3-4 thrombocytopenia. There was no significant difference in OS, DSS, and DFS when compared the two regimens.

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