首页膀胱肿瘤治疗及预后证据详情

Low-dose versus standard-dose bacille Calmette-Guérin for non-muscle-invasive bladder cancer: Systematic review and meta-analysis of randomized controlled trials

原文: 2022 年 发布于 Eur J Nutr 27 卷 第 11 期 1093-1105 浏览量:269次

作者: Choi S. Y. Ha M. S. Kim J. H. Chi B. H. Kim J. W. Chang I. H. Kim T. H. Myung S. C.

作者单位: Urologic Oncology, Mount Sinai Hospital, University of Toronto, 60 Murray St, Toronto, ON, M5T 3L9, Canada. Urologic Oncology, Mount Sinai Hospital, University of Toronto, 60 Murray St, Toronto, ON, M5T 3L9, Canada. Rclark7@pennstatehealth.psu.edu.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1080/14737159.2023.2195554

关键词: androgen suppression therapy bladder cancer incidence meta-analysis recurrence commercial or financial relationships that could be construed as a potential conflict of interest.

文献简介

OBJECTIVE: This study aimed to assess the association between chronic exposure to nitrate in drinking water and the risk of bladder cancer. STUDY DESIGN: Meta-analysis. METHODS: After a systematic retrieval of eligible epidemiological studies, pooled odds ratios (ORs) with 95% confidence intervals (CIs) of bladder cancer for people in the highest vs the lowest categories of nitrate exposure were calculated using the fixed- or random-effects model. We conducted two separate meta-analyses, one considering nitrate exposure as nitrate concentration in drinking water and the other one as daily nitrate intake from drinking water. RESULTS: A total of five studies (three case-control and two cohort studies) were included. The pooled OR (95% CI) of bladder cancer for the highest vs the lowest category of nitrate concentration in drinking water was 0.98 (0.60, 1.57), and daily nitrate intake from drinking water was 1.00 (0.69, 1.45). Both meta-analyses showed high heterogeneity across studies (I(2) = 80.8% and 65.0%, respectively). Removing studies with the high risk of bias increased the risk and reduced the heterogeneity: [(nitrate concentration in drinking water: 1.36 (1.03, 1.79), I(2) = 0.0%) and (daily nitrate intake from drinking water: 1.14 (0.90, 1.46), I(2) = 8.4%)]. CONCLUSION: The current epidemiological evidence failed to establish a conclusive relationship between chronic exposure to nitrate in drinking water and the risk of bladder cancer. While no association and high heterogeneity across studies were detected in the two meta-analyses, removing studies with the high risk of bias increased the risk and dissolved the heterogeneity.

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