首页膀胱肿瘤治疗及预后证据详情

Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis

原文: 2023 年 发布于 Expert Review of Molecular Diagnostics 47 卷 第 5 期 2023-2026,2034 浏览量:295次

作者: Jiang L. Sun G. Zou L. N. Guan Y. Hang Y. Z. Liu Y. A. Zhou Z. R. Zhang X. Q. Huang X. J. Pan H. Z. Rong S. Z. Ma H. K.

作者单位: Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. And Department of Medical Ultrasound, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China. galaxyge1991@163.com. Department of Medical Ultrasound, Liuzhou People's Hospital affiliated to Guangxi Medical University, Liuzhou, Guangxi, China.. ufo884433@163.com. Department of Medical Ultrasound, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China. chenjinglzgryy@163.com. Department of Medical Ultrasound, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, China. zhushangyong@sina.com.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1097/ju.0000000000001548

关键词: 非肌层浸润性膀胱癌 复发因素 Meta分析 地域差异

文献简介

ObjectiveThe relationship between noncoding RNAs and the prognosis of bladder cancer (BC) is still controversial. The purpose of this study is to evaluate the relationship between noncoding RNAs and prognosis by meta-analysis.MethodsComprehensive retrieval of PubMed, Embase, the Cochrane Library, the Web of Science, CNKI, and WanFang databases is related to the correlation between noncoding RNAs and the prognosis of BC. Data were extracted, and the literature quality was evaluated. STATA16.0 served for the meta-analysis.Results1. CircRNAs: High circ-ZFR expression led to poor overall survival (OS) of BC. 2. LncRNAs: Low lnc-GAS5 expression predicted poor OS of BC, high lnc-TUG1 expression predicted poor OS of BC. 3. MiRNAs: High miR-21 expression predicted poor OS of BC, high miR-222 expression led to poor OS of BC, high miR-155 expression predicted poor progression-free survival (PFS) of BC, high miR-143 expression caused poor PFS of BC, low miR-214 expression could result in poor recurrence-free survival (RFS) of BC.ConclusionsHigh circ-ZFR, lnc-TUG1, miR-222, and miR-21 expressions were correlated with poor OS of BC; high miR-155 and miR-143 expression predicted poor PFS of BC; low lnc-GAS5 expression predicted poor OS of BC; low miR-214 expression predicted poor RFS of BC.

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