首页膀胱肿瘤治疗及预后证据详情

Curative Treatment for Muscle Invasive Bladder Cancer in Elderly Patients: A Systematic Review

原文: 2018 年 发布于 Oncotarget 30 卷 第 3 期 159-164 浏览量:200次

作者: Fonteyne V. Ost P. Bellmunt J. Droz J. P. Mongiat-Artus P. Inman B. Paillaud E. Saad F. Ploussard G.

作者单位: Department of Urology, University of Ulm, Ulm, Germany. Department of Urology, Rechts der Isar Medical Centre, Technical University of Munich, Munich, Germany. Faculty of Medicine, University of Toronto, Toronto, ON, Canada. University of Minnesota Medical School, Minneapolis, MN, USA. Department of Urology, Emory University, Atlanta, GA, USA. Yonsei Wonju Medical Library, Yonsei University Wonju College of Medicine, Wonju, South Korea. Urology Section, Minneapolis VA Health Care System, Minneapolis, MN, USA. Department of Urology, University of Minnesota, Minneapolis, MN, USA.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.3233/BLC-211653

文献简介

Prospective epidemiologic studies on the association between body mass index (BMI) and bladder cancer yielded inconsistent findings. This study sought to quantitatively summarize the evidence by performing a dose-response meta-analysis on prospective cohort studies. Eligible studies were retrieved via PubMed and Embase databases, and by manual review of the references. Linear and nonlinear trend analyses were conducted to explore the relationships between BMI and bladder cancer risk. Meta-analyses on the categories of overweight and obesity were also conducted. The summary relative risk (SRR) was estimated. Heterogeneity across the studies was explored through subgroup analyses based on gender, age, year of publication, sample size, assessment of BMI, geographic location, physical activity and family history of cancer. A total of 14 prospective cohort studies involving 12,642 cases were included. Result of the dose-response analysis showed a nonlinear positive relationship between BMI and bladder cancer (SRR = 1.03, 95% CI: 1.01-1.06, P-nonlinearity =0.031), suggesting that per 5 kg/m2 increment on BMI corresponded to a 3.1 % increase of bladder cancer risk, especially BMI exceed 30kg/m2.Furthermore, significant positive association was also observed between obesity category and bladder cancer risk (SRR: 1.10, 95%CI: 1.03-1.17). In summary, this dose-response meta-analysis suggests a nonlinear positive association between BMI and bladder cancer risk. Further studies are required to confirm these findings and elucidate the pathogenic mechanisms.

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