首页膀胱肿瘤治疗及预后证据详情

The clinicopathological characteristics and prognostic value of squamous differentiation in patients with bladder urothelial carcinoma: a meta-analysis

原文: 2020 年 发布于 International Urology and Nephrology 30 卷 第 3 期 7593560 浏览量:215次

作者: Lin X. Deng T. Wu S. Lin S. X. Wang D. Wu C. L.

作者单位: Department of Urology, Medical University of Vienna, Vienna, Austria. Department of Clinical Psychology, University `Dimitrie Cantemir`, Tirgu Mures, Romania. Division of Urology, European Institute of Oncology, Milan, Italy. Department of Neurosciences, Human Reproduction and Odontostomatology, University of Naples, Naples, Italy. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Department of Urology, Weill Cornell Medical College, New York, NY, USA. Department of Cell and Molecular Biology, University of Medicine and Pharmacy, Tirgu Mures, Romania.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.3892/ol.2019.11227

关键词: 膀胱癌 lncRNA UCA1 Meta分析

文献简介

PURPOSE OF REVIEW: The clinical significance of ureteral and urethral recurrence in patients treated with radical cystectomy for bladder cancer is scarce and heterogeneous. The aim of the current review is to summarize the recent literature on incidence, diagnosis and oncologic outcomes of ureteral and urethral recurrences after radical cystectomy. RECENT FINDINGS: Frozen section analysis (FSA) of ureteral margin had a sensitivity and specificity of 69-77 and 83-96%, respectively. Considering the ureteral margin, the reported sensitivity and specificity were 33-93 and 99-100%, respectively. Transurethral biopsy of the prostatic urethra might help in counseling patients' treatment, although its accuracy and prognostic role is highly questionable. In patients treated with radical cystectomy, recurrence of the urethra or ureteral are rare, occurring approximately in 5% of patients. During the follow-up, urinary cytology and cross-sectional imaging improve the early detection of recurrence in asymptomatic patients, although the majority are diagnosed for symptomatic presentation. Their use should be tailored to the patient's risk of ureteral and/or urethral recurrence. Urethrectomy is indicated in case of singular urethral recurrence, whereas no clear data exists regarding the best management of ureteral recurrence, except surgical removal. SUMMARY: Intraoperative FSA of ureters and urethra share good specificity but poor sensitivity. Recurrence at urethra and upper tract are rare and discordant data exists regarding survival outcomes. Oncologic surveillance after radical cystectomy with the aim to detect these recurrences should be tailored to the individualized patient's risk.

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