Quantifying the absolute benefit of neoadjuvant chemotherapy followed by definitive therapy in patients with muscle-invasive bladder cancer: A systematic review and meta-analysis

原文： 2022 年发布于 Eur Urol 151 卷第 07 期 209-214  浏览量：148次

作者： Ikram W. Naqvi S. A. A. Raina A. Fatima E. Siddiqi R. Islam M. Asghar N. Khakwani K. Z. R. Khan A. M. Hussain S. A. Bryce A. H. Bin Riaz I. Singh P.

作者单位： Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Urology, Medical University of Vienna, Vienna, Austria. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Department of Urology, Weill Cornell Medical College, New York, NY, USA. Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic. Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan. European Association of Urology Research Foundation, Arnhem, The Netherlands. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

归属分类：膀胱肿瘤治疗及预后证据

DOI： 10.3233/BLC-201510

关键词：膀胱癌整块切除二次电切肿瘤残留分期升高

Purpose. In this study, a systematic review and meta-analysis were used to examine the effectiveness of nursing care in the treatment of bladder cancer patients. The platforms of PubMed, Embase, Cochrane Library, and Web of Science were used to conduct a thorough literature search. Methods. The searching approach was used to find the fundamental characteristics of 5 studies. Sample size ranged from 52 to 131,852, and total sample size was 151,166. The study was looked up in PubMed, Embase, and Web of Science, with the most recent search being done in July 2022. Utilizing a standardized form, two independent reviewers gathered pertinent information from research that qualified as literature (17). Review Manager 5.3 used the data to examine the literature. Statistics were deemed significant at p < 0.05. Results. We discovered that more bladder cancer patients with T1+T2 tumor stages were receiving nursing care than those with T1+T2 tumor stages were receiving control care (mean difference =1.27, 95% CI: 1.20-1.35, p < 0.00001). The proportion of bladder cancer patients with T3+T4 tumor stage in the nursing care group was lower than the proportion of patients with T3+T4 tumor stage in the control group (mean difference = 1.07; 95% CI: 1.01-1.14; p < 0.00001). The difference between the number of bladder cancer patients receiving radiotherapy in the nursing care group and the control group was not statistically significant (mean difference = 1.07, 95% confidence interval [CI]: 0.99-1.16, p=0.11). There were fewer patients with bladder cancer receiving chemotherapy in the nursing care group than that in the control group (mean difference = -0.02, 95% CI: -0.0-0.02, p < 0.00001). The incidence rate of patients with bladder cancer with major complications in nursing care group was lower than that of patients with bladder cancer with major complications in control group (mean difference = 0.41 95% CI: 0.18-0.93, p=0.03). When compared to patients with bladder cancer who had serious complications in the control group, the hospital death rate for nursing care patients had a greater incidence of bladder cancer patients (mean difference = 4.64 95% CI: 4.46-4.82, p < 0.00001). Conclusion. This study demonstrated that the effects of nursing care reduced the incidence rate of chemotherapy and the frequency of severe problems in bladder cancer patients.