P3H4 and PLOD1 expression associates with poor prognosis in bladder cancer
原文： 2022 年 发布于
Medicine
50 卷 第 3 期 S275-S276
浏览量：188次
作者：
Zhang J.
Dong Y.
Shi Z.
He H.
Chen J.
Zhang S.
Wu W.
Zhang Q.
Han C.
Hao L.
作者单位：
Department of Urology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan. Department of Urology, Ehime University Graduate School of Medicine, Ehime, Japan. Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal, Canada. Department of Urology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. shahrokh.shariat@meduriwien.ac.at. Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. shahrokh.shariat@meduriwien.ac.at. Department of Urology, Weill Cornell Medical College, New York, NY, USA. shahrokh.shariat@meduriwien.ac.at. Department of Urology, University of Texas Southwestern, Dallas, TX, USA. shahrokh.shariat@meduriwien.ac.at. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. shahrokh.shariat@meduriwien.ac.at. Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. shahrokh.shariat@meduriwien.ac.at. Department of Urology, University of Jordan, Amman, Jordan. shahrokh.shariat@meduriwien.ac.at. European Association of Urology Research Foundation, Arnhem, The Netherlands. shahrokh.shariat@meduriwien.ac.at.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.1016/j.urolonc.2020.11.022
关键词：
*Carcinoma
Transitional Cell
Humans
Prognosis
Retrospective Studies
*Urinary Bladder Neoplasms/surgery
*Urinary Tract
PURPOSE: The prolyl 3-hydroxylase family member 4 gene (P3H4) is involved in the development of human cancers. The association of P3H4 with bladder cancer (BC) prognosis is unclear. This study aimed to analyze the association of P3H4 with BC prognosis. METHODS: RNA-Seq data were downloaded from The Cancer Genome Atlas project and BC microarray datasets (GSE13507, GSE31684, and GSE32548) were downloaded from the Gene Expression Omnibus database. We analyzed the differences in P3H4 expression levels between BC tumors and non-tumor tissues and between samples with different clinical information. The association of P3H4 and P3H4-related genes with BC prognosis and the possibility of using P3H4 expression as a prognostic biomarker in BC patients were also analyzed. RevMan was used to perform the meta-analysis. RESULTS: P3H4 was upregulated in BC tissues compared with the adjacent non-tumor tissues (p = 4.06e-08). Univariate Cox regression analysis and meta-analysis showed that high P3H4 expression level contributed to a poor BC prognosis (Hazard ratio, HR = 1.348, 95% CI 1.140-1.594, p = 4.89e-04; meta-analysis: HR = 1.45, 95% CI 1.10-1.91; p = 9.00e-03). Among the genes related to P3H4, the PLOD1 gene was closely associated with P3H4 expression (r = 0.620, p = 2.49e-44). Also, a meta-analysis showed that PLOD1 expression was associated with a poor prognosis in BC patients (HR = 1.77, 95% CI 1.31-2.38; p = 2.00e-04). CONCLUSIONS: The P3H4 and PLOD1 genes might be used as reliable prognostic biomarkers for BC.