首页膀胱肿瘤治疗及预后证据详情

Association between obesity and bladder cancer recurrence: A meta-analysis

原文: 2018 年 发布于 J Cancer Res Ther 45 卷 第 15 期 48263-48271 浏览量:253次

作者: Lin Y. Wang Y. Wu Q. Jin H. Ma G. Liu H. Wang M. Zhang Z. Chu H.

作者单位: Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, King Faisal Medical City, Abha, Saudi Arabia. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX Departments of Urology, Weill Cornell Medical College, New York, NY Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan. Electronic address: sfshariat@gmail.com.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.1038/s41430-021-01014-0

关键词: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant Cisplatin/administration & dosage *Cystectomy/methods Evidence-Based Medicine Humans *Lymph Node Excision Neoadjuvant Therapy/*methods Neoplasm Invasiveness Organ Sparing Treatments/methods Randomized Controlled Trials as Topic Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/mortality/*pathology/*therapy adjuvant chemotherapy bladder cancer bladder-sparing therapy lymph node dissection neoadjuvant chemotherapy radical cystectomy

文献简介

PURPOSE: We sought to examine the literature reporting the effect of urinary tract infection (UTI) on non-schistosomiasis-related UBC (UBC(NS)) through a systematic review and meta-analysis. METHODS: A predefined study protocol was developed according to PRISMA. Medline and Scopus were searched for all studies investigating exposure to UTI with UBCNS as the primary outcome. Potential studies were screened against eligibility criteria. Clinical heterogeneity was assessed and groups with more than two studies were evaluated by random effect meta-analysis. Study-level bias was assessed with the Newcastle-Ottawa Scale (NOS). In cases of substantial between study heterogeneity (I(2) > 50%), predefined sensitivity and subgroup analyses were performed. RESULTS: Of 16 eligible studies, eight case-control studies spanning four decades and five countries were suitable for quantitative analysis. Main analysis favored exposure to UTI increasing risk of subsequent UBC(NS) (RR 1.33 [95% CI 1.14-1.55]). This effect was no longer statistically significant after excluding studies published prior to year 2000 and at high risk of bias. Between study heterogeneity was considerable for nearly all analyses and not reduced by predefined sensitivity or subgroup analyses. CONCLUSION: Exposure to UTI favors increased risk for UBC(NS), particularly in men, but these effects were statistically insignificant when pooling data from the most recent and highest quality studies. These data do not support findings of previously published studies, that report on heterogenous populations with poor definitions of UTI and minimal control for important confounders. Results from previous studies should be viewed as hypothesis generating. This review highlights the need for higher quality investigation.

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