The impact of upfront transurethral resection of bladder tumor (TURBT) and intravesical BCG versus radical cystectomy on survival outcomes of high-risk non-muscle invasive bladder cancer: A meta-analysis of comparative studies
原文： 2022 年 发布于
European Urology
2022 卷 第 03 期 812-819
浏览量：184次
作者：
Haddad P. A.
Khater N. P.
作者单位：
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan. Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Urology, Medical University of Silesia, Zabrze, Poland. Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. Department of Urology, Paracelsus Medical University Salzburg, University Hospital Salzburg, Salzburg, Austria. Department of Urology, Hillel Yaffe Medical Center, Hadera, Israel. Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan. Department of Urology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy. Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC, Canada. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Department of Urology, Weill Cornell Medical College, New York, NY, USA. Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.27288/d.cnki.gsxyu.2022.000125
关键词：
铥激光
2μm激光
膀胱癌
荟萃分析
The effects of the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms on bladder cancer risk have been evaluated in some studies. However, the results were conflicting and ambiguous. Therefore, we aimed to perform a comprehensive meta-analysis to investigate the association of these polymorphisms with risk of bladder cancer from all eligible case-control studies. PubMed, Web of science, Scopus, SID, CNKI and SciELO databases were searched to identify all relevant studies published up to 1 January, 2021. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. A total of 20 case-control studies including 11 studies with 3463 cases and 3927 controls on MTHFR rs1801133 (677C>T) and 9 studies with 3177 cases and 3502 controls on rs180113 (1298A>C) polymorphism were selected. Pooled data revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were not associated with risk bladder cancer in overall. Stratified analysis by ethnicity revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were associated with bladder cancer risk in Asians, but not in Caucasians. There was no publication bias. The current meta-analysis revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were not risk factor for development of bladder cancer globally. However, large sample size, well-designed, and population-based studies should be performed to verify the association of the MTHFR polymorphisms with bladder cancer risk.