Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis
原文： 2020 年 发布于
Urol Int
33 卷 第 4 期 1088
浏览量：199次
作者：
Bausch K.
Aghlmandi S.
Sutter S. U.
Stamm L. M.
Ewald H.
Appenzeller-Herzog C.
Roth J. A.
Widmer A. F.
Seifert H. H.
作者单位：
Department of Urology, China-Japan Friendship Hospital, Yinghuadong Road, Chaoyang District, Beijing 100029, China
China-Japan Friendship School Clinical Medicine, Peking University, Beijing 100029, China. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China. Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Joint Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. China-Japan Friendship School Clinical Medicine, Peking University, Beijing 100029, China
Department of Cardiovascular Surgery, China-Japan Friendship Hospital, Yinghuadong Road, Chaoyang District, Beijing 100029, China. Department of Anesthesiology, China-Japan Friendship Hospital, Yinghuadong Road, Chaoyang District, Beijing 100029, China. Electronic address: 605261443@qq.com. Department of Urology, China-Japan Friendship Hospital, Yinghuadong Road, Chaoyang District, Beijing 100029, China
China-Japan Friendship School Clinical Medicine, Peking University, Beijing 100029, China. Electronic address: zh_yang1@163.com.
归属分类：
膀胱肿瘤治疗及预后证据
DOI：
10.3760/cma.j.cn431460-20210406-00016
关键词：
Adult
Aged
Aged
80 and over
Checklist
Consensus
Databases
Factual
Female
Humans
Male
Middle Aged
*Patient Reported Outcome Measures
Psychometrics/methods/*standards
Surveys and Questionnaires/*standards
*Urinary Bladder Neoplasms
Cosmin
bladder cancer
patient reported outcome measures
psychometric properties
systematic review
The prognostic value of programed death-ligand 1 (PD-L1) in urothelial carcinoma (UC) has been assessed in previous studies, while the results remain controversial and heterogeneous. Therefore, we performed this meta-analysis to explore the prognostic effect of PD-L1 in patients with UC. PubMed, Embase and Web of Science were searched to identify the studies. Hazard ratios (HR) with 95% confidence interval (95% CI) and clinicopathological factors were extracted from included studies. A total of 1819 patients with UC from 11 published studies were incorporated. The results of meta-analysis showed that positive PD-L1 expression was significantly associated with poorer overall survival (OS) (HR 1.59, 95% CI 1.05-2.40) and disease-free survival (DFS) (HR 1.83, 95% CI 1.03-3.25), but not recurrence-free survival. Moreover, in the subgroup analysis, significant associations between PD-L1 expression and OS or DFS were found in bladder UC, the cutoff value of positive expression of PD-L1 ≥ 5% and the expression of PD-L1 on the tumor cell membrane. Interestingly, positive PD-L1 expression was correlated with poorer pathological T stage (OR 2.03, 95% CI 1.46-2.82). Our meta-analysis implies that PD-L1 might be a valuable biomarker of poor prognosis for UC, especially bladder UC, although further large-scale and well-designed studies are warranted to verify the prognostic value of PD-L1 for UC.