首页膀胱肿瘤治疗及预后证据详情

Port-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options

原文: 2017 年 发布于 癌症进展 浏览量:162次

作者: Khetrapal P. Tan W. S. Lamb B. Nathan S. Briggs T. Shankar A. Ramachandran N. Freeman A. Mitra A. Kelly J. D.

作者单位: Department of Urology, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.13201/j.issn.1001-1420.2022.05.003

文献简介

Various intravesical therapies have been introduced into clinical practices for controlling non-muscle invasive bladder cancer (NMIBC). However, evidence with respect to the efficacy and safety of those intravesical therapies is very limited. Hence, we present a network meta-analysis in order to address this limitation in the current literature. The primary outcomes were the risk of tumor recurrence (TR), tumor progression (TP) and disease-specific mortality (DM). Secondary outcomes included the risk of fever, cystitis and haematuria. Conventional pair-wise and network meta-analysis were both performed for each endpoint. The surface under the cumulative ranking curve (SUCRA) was incorporated in our analysis for ranking the corresponding intravesical instillation interventions. In total, 23 randomized clinical trials (RCTs) were finally included in our study after irrelevant papers were screened out. Results of network meta-analysis suggested that Epirubicin (EPI) was less preferable than Bacille Calmette Guerin (BCG), BCG+EPI, BCG+ Isoniazid (INH), BCG+ Mytomicin C (MMC), Gemcitabine (GEM) and MMC with respect to TR. As suggested by the corresponding ranking probabilities and SUCRA, incorporating EPI or MMC into BCG may enhance the efficacy of BCG monotherapy.

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