首页膀胱肿瘤治疗及预后证据详情

En-bloc transurethral resection vs. conventional transurethral resection for primary non-muscle invasive bladder cancer: A meta-analysis

原文: 2022 年 发布于 Br J Nutr 115 卷 第 4 期 S1066-S1067 浏览量:272次

作者: Di Y. Li H. He C. Peng H.

作者单位: School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China. Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 OBA, UK. S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

归属分类: 膀胱肿瘤治疗及预后证据

DOI: 10.27288/d.cnki.gsxyu.2022.000157

关键词: Humans Male *Urinary Bladder Neoplasms/surgery Urologic Surgical Procedures

文献简介

We reviewed the studies examining whether quitting smoking at or around diagnosis favourably affects the prognosis of bladder cancer (BC) patients, who are often active smokers at diagnosis. We found only nine eligible articles published until 31 January 2022, which encompassed around 5500 BC in total, the majority of which were nonmuscle invasive BC (only one paper included muscle-invasive BC). We used random effects meta-analysis to obtain a summary hazard ratio (SHR) and 95% confidence intervals (CI). The median proportion of smokers who quit at or around diagnosis was 29.8% (range 8.4-43.1%). For the overall, BC-specific, and progression-free survival, the studies were limited in number (n = 3) and provided conflicting results. At the same time, quitters did not appear to have a lower risk of recurrence than continued smokers (SHR 0.99, 95% CI 0.61-1.61). In conclusion, while the evidence is currently not sufficient to draw firm conclusions (especially for patients with muscle-invasive BC), physicians should not refrain from educating smoking BC patients about the benefits of smoking cessation and provide the necessary support.

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