Systematic Review and Meta-Analysis on the Efficacy of Chemotherapy with Transurethral Resection of Bladder Tumors as Definitive Therapy for Muscle Invasive Bladder Cancer

原文： 2017 年发布于 PLoS One  浏览量：228次

作者： Moran G. W. Li G. Robins D. J. Matulay J. T. McKiernan J. M. Anderson C. B.

作者单位： Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, University Hospital of Tours, Tours, France. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, The Jikei University School of Medicine, Tokyo, Japan. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Department of Urology, King Faisal Medical City, Abha, Saudi Arabia. Department of Urology, Luzerner Kantonsspital, Lucerne, Switzerland Department of Urology, Institut Mutualiste Montsouris, Paris, France Department of Urology and Division of Experimental Oncology, Urological Research Institute, Vita-Salute San Raffaele, Milano, Italy. Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal, Canada. Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan The National Center for Diabetes, Endocrinology and Genetics, The University of Jordan, Amman, Jordan. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan The National Center for Diabetes, Endocrinology and Genetics, The University of Jordan, Amman, Jordan Department of Urology, Weill Cornell Medical College, New York, NY, Department of Urology, University of Texas Southwestern, Dallas, TX Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. Electronic address: shahrokh.shariat@meduniwien.ac.at.

归属分类：膀胱肿瘤治疗及预后证据

DOI： 10.21037/tau-21-564

评价透明质酸诊断膀胱癌准确性的准确性。计算机检索 7 个国内外数据库 , 全面收集以国人为研究对象的透明质酸诊断膀胱癌的研究 , 依据 QUADAS-2 评价纳入诊断试验的质量 , 并对结果进行 Meta 分析。最终纳入 14 个研究。结果显示 : 与膀胱镜活检或术后病理检查结果相比 , 透明质酸诊断膀胱癌的诊断比值比、敏感度、特异度、阳性似然比、阴性似然比及 SROC 曲线下面积分别为 32.76(95%CI:18.60,57.71) 、 0.84(95%CI:0.81,0.87) 、 0.86(95%CI:0.83,0.89) 、 5.66(95%CI:4.05,7.91) 、 0.19(95%CI:0.13,0.26) 和 0.9194 。与膀胱镜活检或术后病理检查相比 , 透明质酸具有一定敏感度和特异度 , 且方便、无创 , 对膀胱癌的监测有较高的临床价值。