Adjuvant Chemotherapy Bladder-sparing Chemoradiation Enhanced Recovery after Surgery Muscle-invasive Bladder Cancer Neoadjuvant Chemotherapy Radical Cystectomy Transurethral Resection of Bladder Tumor Trimodal Urothelial Carcinoma of Bladder Variant Histology

Humans *Transurethral Resection of Bladder Neoplasm Recurrence Local/pathology *Urinary Bladder Neoplasms/diagnosis/surgery/pathology Prognosis Urologic Surgical Procedures Cystectomy Bladder cancer Css Os Pfs Rfs Transurethral resection of bladder tumors financial ties to disclose.

Humans *Urinary Diversion/adverse effects *Ureter/surgery Cystectomy/methods Anastomosis Surgical/adverse effects *Vesico-Ureteral Reflux/etiology *Urinary Bladder Neoplasms/surgery Ileum/surgery *Pyelonephritis/complications Bladder Orthotopic ileal neobladder Radical cystectomy Tumor Ureteroenteric anastomosis Urinary diversion

Humans Cystectomy/adverse effects/methods *Urinary Bladder Neoplasms/surgery/etiology Urinary Bladder *Urinary Diversion/adverse effects/methods *Acidosis/epidemiology/etiology/therapy Acidosis metabólica Bicarbonate Bicarbonato Bladder tumor Cistectomía radical Derivación urinaria Metabolic acidosis Radical cystectomy Tratamiento Treatment Tumor vesical Urinary diversion

Humans *Urinary Bladder Neoplasms/surgery/pathology Urologic Surgical Procedures Cystectomy *Laser Therapy *Lasers Solid-State/therapeutic use Turbt bladder tumor laser resection recurrence

detrusor muscle en bloc resection of bladder tumor non-muscle invasive bladder cancer

Humans *Obturator Nerve/physiology/surgery Network Meta-Analysis Transurethral Resection of Bladder *Urinary Bladder Neoplasms/surgery/pathology Reflex bladder cancer lumbar anesthesia obturator nerve block transurethral resection of bladder tumor conflicts of interest to declare.

Humans *Urinary Bladder Neoplasms/surgery/pathology Lasers Urethra/surgery Treatment Outcome Length of Stay 2-micron laser bladder cancer meta-analysis randomized controlled trials trans-urethral resection of bladder tumor

Biomarkers Tumor *Carcinoma Transitional Cell/diagnosis Female Humans Male Nuclear Proteins Sensitivity and Specificity *Urinary Bladder Neoplasms/diagnosis/pathology bladder tumor diagnosis meta analysis nuclear matrix protein urine cytology

Autoantigens Biomarkers Tumor/genetics/metabolism Gene Expression Regulation Neoplastic Humans Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase/genetics/metabolism Prognosis *Urinary Bladder Neoplasms/pathology Bladder cancer Meta-analysis Microarray datasets Overall survival Prognostic biomarker

Humans Biomarkers Tumor *Carcinoma in Situ/diagnosis *Carcinoma Transitional Cell/pathology Hyaluronan Receptors/metabolism Keratin-20/analysis/metabolism Ki-67 Antigen/metabolism Tumor Suppressor Protein p53/analysis/metabolism Urinary Bladder *Urinary Bladder Neoplasms/pathology Urothelium/chemistry/metabolism/pathology Bladder carcinoma Carcinoma in situ Carcinoma vesical Displasia Dysplasia Immunomarkes Inmunomarcadores

Cystectomy/*methods Electrosurgery/*methods Humans Neoplasm Invasiveness Treatment Outcome Urethra Urinary Bladder Neoplasms/pathology/*surgery Bipolar Meta-analysis Monopolar Transurethral bladder tumor resection

Antineoplastic Agents/*therapeutic use Biomarkers Tumor/*blood Humans Male Neoadjuvant Therapy/*methods Prognosis Urinary Bladder Neoplasms/blood/drug therapy/*pathology Biomarkers Bladder cancer Nac Neoadjuvant chemotherapy Systematic review Ucb

Biomarkers Tumor/*metabolism Estrogen Receptor alpha/*metabolism Estrogen Receptor beta/*metabolism GATA3 Transcription Factor/*metabolism Humans Prognosis Urinary Bladder Neoplasms/diagnosis/*metabolism Gata3 bladder cancer estrogen receptors immunohistochemistry tumour markers commercial or financial relationships that could be construed as a potential conflict of interest.

Biomarkers Tumor/*urine Humans Ribonuclease Pancreatic/*urine Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/urine

Chemotherapy Adjuvant Humans Liquid Biopsy Muscles Neoplasm Invasiveness Prospective Studies *Urinary Bladder Neoplasms/drug therapy Cell-free DNA Circulating tumor cells Liquid biopsies Muscle-invasive bladder cancer Perioperative therapy

Biomarkers Tumor/*analysis Carcinoma Transitional Cell/*chemistry/*drug therapy Humans Neoadjuvant Therapy Prognosis Urinary Bladder Neoplasms/*chemistry/*drug therapy Biomarkers Nac Neoadjuvant systemic therapy Ucb bladder cancer systematic review

Cystectomy/adverse effects/*methods Disease-Free Survival Follow-Up Studies Humans Incidence Intraoperative Complications/*epidemiology/etiology Length of Stay/statistics & numerical data Neoplasm Recurrence Local/*epidemiology/etiology/prevention & control Randomized Controlled Trials as Topic Urinary Bladder/*injuries/pathology/surgery Urinary Bladder Neoplasms/mortality/pathology/*surgery Bipolar bladder tumors meta-analysis monopolar transurethral resection

Adjuvants Immunologic/*administration & dosage Administration Intravesical BCG Vaccine/*administration & dosage Humans *Lymphocytes Tumor-Infiltrating Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/immunology/*pathology

Biomarkers Tumor Cystoscopy Humans Neoplasm Recurrence Local/diagnosis Network Meta-Analysis *Urinary Bladder Neoplasms/diagnosis Accuracy Bladder cancer Urinary biomarkers Urine cytology