5-alpha Reductase Inhibitors/administration & dosage/*adverse effects Alopecia/drug therapy Depression/*chemically induced/epidemiology Finasteride/administration & dosage/*adverse effects Humans Male Prostatic Hyperplasia/drug therapy Sexual Dysfunction Physiological/chemically induced/epidemiology Suicidal Ideation

Acrylic Resins/administration & dosage Embolization Therapeutic Gelatin/administration & dosage Humans Male Particle Size Polyvinyl Alcohol/administration & dosage Prostate/*blood supply Prostatic Hyperplasia/*therapy Radiography Interventional

Aged Aged 80 and over Humans Male Middle Aged Outcome Assessment Health Care Plant Extracts/administration & dosage Prostatic Hyperplasia/*drug therapy Serenoa Tamsulosin/administration & dosage Urological Agents/administration & dosage *Serenoa repens *benign prostatic hyperplasia *meta-analysis *randomized controlled trials *tamsulosin conflicts of interest with respect to the research authorship and/or publication of this article.

Adrenergic alpha-Antagonists/*administration & dosage/pharmacology Drug Interactions Drug Therapy Combination Erectile Dysfunction/complications/*drug therapy/physiopathology Hemodynamics/*drug effects Humans Lower Urinary Tract Symptoms/complications/*drug therapy/physiopathology Male Phosphodiesterase 5 Inhibitors/*administration & dosage/pharmacology Prostatic Hyperplasia/complications/*drug therapy/physiopathology Randomized Controlled Trials as Topic Alpha blocker Benign prostatic hyperplasia Erectile dysfunction Hemodynamic interaction Luts Phosphodiesterase-5 inhibitors

5-alpha Reductase Inhibitors/*administration & dosage Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Drug Therapy Combination Dutasteride/*administration & dosage Erectile Dysfunction/chemically induced/diagnosis Humans Male Prostatic Hyperplasia/diagnosis/*drug therapy/epidemiology Randomized Controlled Trials as Topic/methods Tamsulosin/*administration & dosage Treatment Outcome Benign prostatic hyperplasia Dutasteride Meta-analysis Randomized controlled trials Tamsulosin published studies thus no ethical approval and patient consent are required. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Administration Oral Fibrinolytic Agents/*administration & dosage Humans Lasers Solid-State Male Prostatic Hyperplasia Risk Factors Antithrombotic Benign prostate hyperplasia (BPH) Holmium laser enucleation of the prostate (HoLEP) Perioperative safety

Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Adrenergic beta-3 Receptor Agonists/administration & dosage Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans Lower Urinary Tract Symptoms/*drug therapy Male Phosphodiesterase 5 Inhibitors/*administration & dosage Prostatic Hyperplasia/complications Quality of Life Randomized Controlled Trials as Topic 5-alpha reductase inhibitor Lower urinary tract symptoms alpha blockers anticholinergic: systematic review benign prostatic hyperplasia randomized trials

Administration Oral Chronic Disease Flowers/physiology Humans Male Medicine Traditional Phytotherapy Plant Extracts/*administration & dosage Pollen/*physiology Prostatic Hyperplasia/drug therapy Prostatitis/drug therapy Treatment Outcome clinical practice efficacy evidence-based complementary and alternative medicine phytotherapy pollen review

Humans Lower Urinary Tract Symptoms Male Phosphodiesterase 5 Inhibitors/administration & dosage/adverse effects Placebos Prostatic Hyperplasia/complications/*etiology Quality of Life Regression Analysis Severity of Illness Index Lower urinary tract symptoms Meta-analysis Phosphodiesterase 5 inhibitor Placebo Prostatic hyperplasia

Antifibrinolytic Agents/*administration & dosage Blood Loss Surgical/*prevention & control Blood Transfusion/statistics & numerical data Humans Incidence Male Prostatectomy/*adverse effects Prostatic Hyperplasia/surgery Prostatic Neoplasms/surgery Thromboembolism/*epidemiology/etiology Tranexamic Acid/*administration & dosage *Anesthesia *Blood loss *Prostate *Review *Surgical *Systematic *Tranexamic acid

Adrenergic alpha-Antagonists/administration & dosage/*therapeutic use Cholinergic Antagonists/administration & dosage Drug Therapy Combination Humans *Lower Urinary Tract Symptoms Male Prostatic Hyperplasia/*diagnosis/*drug therapy Publication Bias Quality of Life Treatment Outcome

Adrenergic alpha-1 Receptor Antagonists/*administration & dosage Adrenergic alpha-Antagonists Dose-Response Relationship Drug Humans Male Middle Aged Prostatic Hyperplasia *Quality of Life Sulfonamides/*administration & dosage Tamsulosin Prostatic hyperplasia alpha blockers

Botulinum Toxins Type A/administration & dosage Humans Injections Male Neuromuscular Agents/administration & dosage Prostatic Hyperplasia/*drug therapy Treatment Outcome Benign prostatic hyperplasia Botulinum toxin Meta-analysis Placebo

Humans *Gemcitabine Docetaxel/therapeutic use BCG Vaccine/adverse effects Adjuvants Immunologic *Urinary Bladder Neoplasms/therapy Administration Intravesical Neoplasm Invasiveness Neoplasm Recurrence Local

Humans *BCG Vaccine/adverse effects *Urinary Bladder Neoplasms/drug therapy BCG vaccine administration intravesical systematic review urinary bladder neoplasms

Humans *Adjuvants Immunologic/therapeutic use/adverse effects Administration Intravesical Neoplasm Recurrence Local/epidemiology *Urinary Bladder Neoplasms/pathology Drug Administration Schedule Bcg Cvnmi Desabastecimiento Dosis completa Dosis reducida Full dose Nmibc Reduced dose Shortage

Humans Mitomycin Gemcitabine Hematuria *Non-Muscle Invasive Bladder Neoplasms Deoxycytidine/therapeutic use Administration Intravesical *Urinary Bladder Neoplasms/drug therapy *Cystitis Chemical cystitis Cistitis química Cáncer de vejiga sin invasión muscular Gemcitabina intravesical Intravesical gemcitabine Intravesical mitomycin Mitomicina intravesical Non-muscle invasive bladder cancer Recurrence rates Tasas de recurrencia

Humans Mitomycin/therapeutic use Antibiotics Antineoplastic BCG Vaccine/therapeutic use *Non-Muscle Invasive Bladder Neoplasms Neoplasm Recurrence Local/drug therapy *Urinary Bladder Neoplasms/pathology Administration Intravesical Neoplasm Invasiveness Bladder cancer Device-assisted Emda Intravesical drug administration Nmibc

Humans *Carcinoma Transitional Cell *Urinary Bladder Neoplasms/pathology Retrospective Studies BCG Vaccine/therapeutic use Administration Intravesical Adjuvants Immunologic *Organ Transplantation Neoplasm Invasiveness Neoplasm Recurrence Local/pathology Bcg Bladder cancer Chemotherapy Mitomycin Transplanted patients

Administration Intravesical Combined Modality Therapy Cystectomy/*methods Humans Neoplasm Recurrence Local/*epidemiology Network Meta-Analysis Randomized Controlled Trials as Topic Urethra Urinary Bladder Neoplasms/*diagnostic imaging/drug therapy/epidemiology/*surgery #BladderCancer #blcsm #uroonc blue-light cystoscopy hexaminolevulinic acid narrow band imaging non-muscle-invasive urothelial carcinoma photodynamic diagnosis single immediate intravesical chemotherapy