*DNA Methylation Disease Progression Female Genes APC/*physiology Humans Male *Promoter Regions Genetic *Urinary Bladder Neoplasms/genetics/pathology/urine

Cystectomy/*methods Humans Length of Stay Postoperative Care/*methods Postoperative Complications/*epidemiology Prospective Studies Recovery of Function Retrospective Studies Standard of Care Urinary Bladder Neoplasms/rehabilitation/*surgery bladder cancer enhanced recovery after surgery meta-analysis postoperative rehabilitation radical cystectomy

Adolescent Adult Aged Aged 80 and over Animals Cultured Milk Products *Dairy Products *Diet Dietary Fats/administration & dosage *Feeding Behavior Female Humans Male Middle Aged Milk *Urinary Bladder Neoplasms/etiology/prevention & control Young Adult dairy products fermented dairy products whole milk bladder cancer meta-analysis systematic review

*Cystectomy/adverse effects/methods Humans Neoplasm Staging Neoplasm Residual/pathology/surgery *Reoperation/methods/statistics & numerical data *Urinary Bladder Neoplasms/pathology/surgery Cystoscopy Meta-analysis Neoplasm recurrence Urinary bladder neoplasms

Female Humans Male Prospective Studies *Quality of Life Urinary Bladder Neoplasms/drug therapy/*psychology/radiotherapy Bladder cancer Chemotherapy Muscle-invasive bladder cancer Quality of life Urothelial cancer PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Biopsy/methods Carcinoma in Situ/*pathology/*therapy Humans Muscle Smooth Neoplasm Invasiveness Urinary Bladder Neoplasms/*pathology/therapy Biopsias aleatorias de vejiga Carcinoma in situ Non-muscle invasive bladder cancer Random bladder biopsies Tumor vesical no-músculo invasivo

*Cystectomy *Health Status Humans Patient Education as Topic/*methods Preoperative Care/*methods Relaxation Therapy/*methods Urinary Bladder Neoplasms/*surgery Bladder cancer Cystectomy Supportive intervention Systematic review PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Circulating Tumor DNA/*analysis/blood/urine Humans Reproducibility of Results Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis/pathology CfDNA biomarkers diagnosis meta-analysis

Cystectomy/*methods Humans *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery Oncologic outcome Open radical cystectomy Positive surgical margin Robot-assisted radical cystectomy

Aminolevulinic Acid/*chemistry Cystoscopy/methods Humans Image Interpretation Computer-Assisted/*methods Narrow Band Imaging/methods Photosensitizing Agents/*chemistry Urinary Bladder Neoplasms/metabolism/pathology/*surgery Narrow band imaging bladder cancer diagnostic performance photodynamic diagnosis white light-guided cystoscopy

Diabetes Mellitus Type 2/complications/drug therapy Humans Hypoglycemic Agents/*adverse effects/therapeutic use Odds Ratio Pioglitazone/*adverse effects/therapeutic use Randomized Controlled Trials as Topic Risk Assessment Risk Factors Time Factors Urinary Bladder Neoplasms/*etiology Bladder cancer dose-response relationship meta-analysis pioglitazone

Cystectomy Humans Procedures and Techniques Utilization/*statistics & numerical data Prospective Studies Retrospective Studies Risk Assessment Urinary Bladder Neoplasms/*surgery Predictors Radical cystectomy Use Utilization interest including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg employment/affiliation grants or funding consultancies honoraria stock ownership or options expert testimony royalties or patents filed received or pending) are the following: None.

Periodontal diseases cohort studies meta-analysis periodontitis urinary bladder neoplasms

Blood Loss Surgical *Cystectomy Diet Humans Lymph Nodes/pathology *Minimally Invasive Surgical Procedures Postoperative Complications/etiology Randomized Controlled Trials as Topic Recurrence Treatment Outcome Urinary Bladder Neoplasms/*surgery Open radical cystectomy laparoscopic radical cystectomy meta-analysis minimally invasive randomized controlled trials robot-assisted radical cystectomy

Administration Intravesical Antineoplastic Agents/*administration & dosage Humans Infusions Intra-Arterial Meta-Analysis as Topic Systematic Reviews as Topic Urinary Bladder Neoplasms/*drug therapy

Databases Factual Disease-Free Survival Humans Lymphocytes/*cytology/immunology Neoplasm Metastasis Neutrophils/*cytology/immunology Odds Ratio Prognosis Proportional Hazards Models Risk Assessment Survival Rate Urinary Bladder Neoplasms/immunology/mortality/*pathology Urologic Neoplasms/immunology/mortality/*pathology Bladder cancer Metastatic unresectable urothelial carcinoma Neutrophil-Lymphocyte ratio Unresectable urothelial carcinoma

Adjuvants Immunologic/*therapeutic use Administration Intravesical BCG Vaccine/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Cystoscopy Female Humans Male Multivariate Analysis Muscle Smooth/*pathology Neoplasm Invasiveness Neoplasm Recurrence Local/*epidemiology Proportional Hazards Models Sex Factors Survival Rate Urinary Bladder Neoplasms/pathology/*therapy *Urologic Surgical Procedures Bladder cancer Gender differences Local recurrence Meta-analysis Transurethral resection of bladder tumor

*Conversion to Open Surgery *Cystectomy Humans Odds Ratio Operative Time Postoperative Complications/etiology *Robotic Surgical Procedures Treatment Outcome Urinary Bladder Neoplasms/*surgery complications meta-analysis open radical cystectomy robotic

Contrast Media Diagnosis Differential Female Humans Lymphatic Metastasis/*diagnostic imaging/pathology Magnetic Resonance Imaging/*methods Male Prostatic Neoplasms/*pathology Sensitivity and Specificity Urinary Bladder Neoplasms/*pathology Mri bladder cancer lymph node metastasis meta-analysis prostate cancer

Aged Biomarkers Tumor/*blood Cystectomy/*adverse effects Female Humans Leukocyte Count Lymphocytes/*pathology Male Middle Aged Monocytes/*pathology Neoplasm Recurrence Local/blood/*epidemiology Postoperative Complications/blood/*epidemiology Survival Analysis Urinary Bladder Neoplasms/*blood/pathology/surgery