Alleles Case-Control Studies *Genetic Predisposition to Disease Genotype Glutathione Transferase/*genetics Humans Odds Ratio *Polymorphism Genetic Publication Bias Risk Urinary Bladder Neoplasms/epidemiology/*genetics Gstm1 Gstt1 bladder cancer polymorphism

Biomarkers Tumor/*urine Cystoscopy/methods *DNA Methylation Humans Urinary Bladder Neoplasms/*diagnosis/urine biomarkers methylation molecular diagnostics neoplasms urinary bladder urine analysis

Age Factors Biomarkers Tumor DNA Methylation/genetics Humans Neoplasm Staging Promoter Regions Genetic Proportional Hazards Models Sex Factors Survival Analysis Tumor Suppressor Proteins/*genetics Urinary Bladder Neoplasms/*genetics/*pathology

Asian People/*genetics *Genetic Predisposition to Disease Glutathione Transferase/*genetics Humans Polymorphism Single Nucleotide Urinary Bladder Neoplasms/*genetics Bladder cancer glutathione S-transferase M1 glutathione S-transferase T1 meta-analysis

Aged Aged 80 and over Chemoradiotherapy/*mortality/*statistics & numerical data Combined Modality Therapy Cystectomy/*mortality/*statistics & numerical data Disease-Free Survival Female Humans Male Middle Aged Neoplasm Invasiveness Postoperative Complications/mortality/prevention & control Prevalence Radiation Injuries/mortality/prevention & control Risk Factors Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/*therapy

Cystectomy/*methods Humans Length of Stay Operative Time Postoperative Complications Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery bladder cancer cystectomy robotics

Asian People/genetics Biomarkers Tumor/*blood/urine Cystoscopy/adverse effects Humans MicroRNAs/*blood Neoplasm Staging Nuclear Proteins/urine Odds Ratio ROC Curve Regression Analysis Sensitivity and Specificity Urinalysis/methods Urinary Bladder Neoplasms/*blood/diagnosis/*genetics/urine Bladder cancer Diagnosis Meta-analysis miRNA authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

*Biomarkers Tumor Disease Progression Gene Expression Humans Matrix Metalloproteinases/*genetics/metabolism Prognosis Publication Bias Survival Analysis Urinary Bladder Neoplasms/*genetics/metabolism/*mortality/pathology bladder cancer matrix metalloproteinases meta-analysis

Adjuvants Immunologic/*administration & dosage/adverse effects Administration Intravesical Antineoplastic Agents/*administration & dosage/adverse effects BCG Vaccine Carcinoma in Situ/mortality/pathology/*therapy Combined Modality Therapy/adverse effects/methods Disease Progression Drug Administration Schedule Humans Interferon-alpha/*administration & dosage/adverse effects Neoplasm Recurrence Local Randomized Controlled Trials as Topic Time Factors Urinary Bladder Neoplasms/mortality/pathology/*therapy Withholding Treatment/statistics & numerical data

Arylamine N-Acetyltransferase/*genetics Genetic Predisposition to Disease Humans Isoenzymes/genetics Polymorphism Genetic Urinary Bladder Neoplasms/*genetics

Arylsulfotransferase/*genetics Case-Control Studies Genetic Association Studies Genetic Predisposition to Disease Genotype Humans NAD(P)H Dehydrogenase (Quinone)/*genetics Odds Ratio *Polymorphism Genetic Risk Factors Smoking/*adverse effects Urinary Bladder Neoplasms/enzymology/*genetics Nqo1 Sult1a1 meta-analysis polymorphisms smoking urinary bladder neoplasms

Administration Intravesical Antibiotics Antineoplastic/*administration & dosage BCG Vaccine/administration & dosage Carcinoma in Situ/*drug therapy/mortality/pathology Carcinoma Transitional Cell/*drug therapy/mortality/pathology Disease Progression Electrochemotherapy/adverse effects/*methods Humans Mitomycin/*administration & dosage Neoplasm Recurrence Local Randomized Controlled Trials as Topic Time Factors Urinary Bladder Neoplasms/*drug therapy/mortality/pathology

Biomarkers Tumor/genetics/urine Humans RNA/urine Sensitivity and Specificity Software Survivin/genetics/*urine Urinary Bladder Neoplasms/*diagnosis/*urine Bladder cancer Diagnosis Meta-analysis Survivin

Acetylation Arylamine N-Acetyltransferase/*genetics/metabolism Asian People/genetics Case-Control Studies China/epidemiology Genetic Association Studies Genetic Predisposition to Disease Humans Odds Ratio Phenotype *Polymorphism Single Nucleotide Risk Assessment Risk Factors Urinary Bladder Neoplasms/enzymology/ethnology/*genetics

Cation Transport Proteins/*genetics Glutathione Peroxidase/*genetics Humans Neoplasm Recurrence Local/genetics Polymorphism Genetic Survival Analysis Urinary Bladder Neoplasms/genetics/*pathology Glutathione Peroxidase GPX1 Nmibc Nramp1 d534n hGPX1 Pro168Leu meta-analysis recurrence

Asian People/genetics Female Humans Male Microtubule-Associated Proteins/*genetics *Polymorphism Single Nucleotide Urinary Bladder Neoplasms/ethnology/*genetics/pathology White People/genetics

Aged Aged 80 and over *Biomarkers Tumor Cluster Analysis Cohort Studies Female Gene Expression Profiling Humans Immunohistochemistry Male Middle Aged Mutation Neoplasm Invasiveness Neoplasm Staging Neoplasms Basal Cell/*diagnosis/genetics/*metabolism/mortality Prognosis Survival Analysis Tissue Array Analysis Urinary Bladder Neoplasms/*diagnosis/genetics/*metabolism/mortality Biomarker Bladder cancer

Antibiotics Antineoplastic/*therapeutic use BCG Vaccine/*therapeutic use Combined Modality Therapy Humans Mitomycin/*therapeutic use Urinary Bladder Neoplasms/*drug therapy bacillus Calmette-Guérin mitomycin C non-muscle-invasive bladder carcinoma recurrence rate meta-analysis.

Biomarkers Tumor/*genetics Epigenesis Genetic/*genetics Humans Methylation Mycobacterium bovis/*genetics Prognosis Urinary Bladder Neoplasms/*genetics/pathology/surgery

Area Under Curve Biomarkers Tumor/*urine Case-Control Studies Humans Odds Ratio RNA Long Noncoding/*urine Sensitivity and Specificity Software Urinary Bladder Neoplasms/*diagnosis/ethnology/genetics/urine Uca1 biomarker bladder cancer noninvasive diagnosis urinary marker