Humans Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence Local/*pathology Neoplasm Staging Neoplasm Residual *Reoperation Risk Factors Survival Rate Urinary Bladder/pathology Urinary Bladder Neoplasms/*pathology/*surgery Bladder Cancer Detrusor Muscle Progression Re-resection Recurrence Upstaging

Antineoplastic Agents/*therapeutic use Carcinoma Transitional Cell/pathology/*therapy Chemotherapy Adjuvant Cystectomy Cystoscopy Humans Lymph Node Excision Muscle Smooth/*pathology *Neoadjuvant Therapy Neoplasm Invasiveness *Organ Sparing Treatments Progression-Free Survival Proportional Hazards Models *Radiotherapy Adjuvant Survival Rate Urinary Bladder Neoplasms/pathology/*therapy Bladder preserving Cancer Muscle invasive Radical cystectomy Trimodal

Aged Aged 80 and over Chemoradiotherapy/*mortality/*statistics & numerical data Combined Modality Therapy Cystectomy/*mortality/*statistics & numerical data Disease-Free Survival Female Humans Male Middle Aged Neoplasm Invasiveness Postoperative Complications/mortality/prevention & control Prevalence Radiation Injuries/mortality/prevention & control Risk Factors Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/*therapy

Administration Intravesical Antineoplastic Agents/*administration & dosage/adverse effects Asymptomatic Diseases BCG Vaccine/*administration & dosage/adverse effects Bacteriuria/*complications/diagnosis Humans Immunotherapy/adverse effects/*methods Neoplasm Invasiveness Risk Assessment Treatment Outcome Urinary Bladder Neoplasms/complications/*drug therapy/immunology/pathology Bacillus Calmette-Guerin Bacteriuria Bladder cancer Intravesical instillation

Adult Aged Aged 80 and over Humans Magnetic Resonance Imaging/standards Middle Aged Muscle Neoplasms/*diagnosis Neoplasm Invasiveness Sensitivity and Specificity Urinary Bladder Neoplasms/*diagnosis Bladder cancer Local staging Magnetic resonance imaging Meta-analysis Muscle-invasive bladder cancer Systematic review

Administration Intravesical BCG Vaccine/therapeutic use Disease Progression Female Humans *Ki-67 Antigen Male *Neoplasm Invasiveness Prognosis Prospective Studies *Urinary Bladder Neoplasms/diagnosis/drug therapy/pathology Ki67 meta-analysis non-muscular-invasive bladder cancer

Humans *Lymph Node Excision Lymphatic Metastasis Muscle Smooth/pathology Neoplasm Invasiveness Prognosis Urinary Bladder Neoplasms/pathology/*surgery Cáncer vesical con infiltración de la muscular Linfadenectomía Lymph node anatomical territory Lymphadenectomy Muscle invasive bladder cancer Oncological value Territorios anatómicos ganglionares Valor oncológico

Age Factors Aged Aged 80 and over Clinical Decision-Making *Cystectomy/adverse effects/mortality Disease-Free Survival Female Geriatric Assessment Humans Life Expectancy Male Middle Aged Neoplasm Invasiveness Odds Ratio Patient Selection Quality of Life Radiotherapy/adverse effects/mortality Risk Factors Time Factors Treatment Outcome Urinary Bladder Neoplasms/mortality/pathology/*therapy Complications Elderly Mibc Outcome

Administration Intravesical Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse effects BCG Vaccine/administration & dosage Bayes Theorem Deoxycytidine/administration & dosage/analogs & derivatives Disease Progression Epirubicin/administration & dosage Female Humans Isoniazid/administration & dosage Male Middle Aged Mitomycin/administration & dosage Neoplasm Invasiveness Neoplasm Recurrence Local Odds Ratio Randomized Controlled Trials as Topic Risk Factors Time Factors Treatment Outcome Urinary Bladder Neoplasms/*drug therapy/mortality/pathology Gemcitabine efficacy and safety intravesical therapy non-muscle invasive bladder cancer tumor progression tumor recurrence

Aged Aged 80 and over *Biomarkers Tumor Cluster Analysis Cohort Studies Female Gene Expression Profiling Humans Immunohistochemistry Male Middle Aged Mutation Neoplasm Invasiveness Neoplasm Staging Neoplasms Basal Cell/*diagnosis/genetics/*metabolism/mortality Prognosis Survival Analysis Tissue Array Analysis Urinary Bladder Neoplasms/*diagnosis/genetics/*metabolism/mortality Biomarker Bladder cancer

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant Cisplatin/administration & dosage Humans Neoadjuvant Therapy Neoplasm Invasiveness Urinary Bladder Neoplasms/*drug therapy/mortality/pathology Bladder cancer Chemotherapy Neoadjuvant Platinum Survival article.

Antineoplastic Combined Chemotherapy Protocols/therapeutic use Bayes Theorem Carcinoma Transitional Cell/*drug therapy/pathology/surgery Cisplatin/therapeutic use Cystectomy Deoxycytidine/analogs & derivatives/therapeutic use Doxorubicin/therapeutic use Humans Methotrexate/therapeutic use *Neoadjuvant Therapy Neoplasm Invasiveness/pathology Urinary Bladder Neoplasms/*drug therapy/pathology/surgery Vinblastine/therapeutic use Gemcitabine

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Chemotherapy Adjuvant Cisplatin/administration & dosage *Cystectomy/methods Evidence-Based Medicine Humans *Lymph Node Excision Neoadjuvant Therapy/*methods Neoplasm Invasiveness Organ Sparing Treatments/methods Randomized Controlled Trials as Topic Survival Analysis Treatment Outcome Urinary Bladder Neoplasms/mortality/*pathology/*therapy adjuvant chemotherapy bladder cancer bladder-sparing therapy lymph node dissection neoadjuvant chemotherapy radical cystectomy

Biomarkers Tumor/*blood/*genetics Humans MicroRNAs/*blood/*genetics Neoplasm Invasiveness Reverse Transcriptase Polymerase Chain Reaction Urinary Bladder Neoplasms/*blood/*genetics/pathology

Carcinoma Transitional Cell/pathology/*surgery Electrocoagulation/*methods Humans Length of Stay Muscle Smooth/pathology Neoplasm Invasiveness *Neoplasm Recurrence Local Operative Time Prospective Studies Retrospective Studies Urinary Bladder/pathology/*surgery Urinary Bladder Neoplasms/pathology/*surgery