Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Carcinoma Transitional Cell/*drug therapy/pathology Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Humans Neoplasm Metastasis Neoplasm Staging Practice Guidelines as Topic Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy/pathology Immune checkpoint inhibitors Platinum-based chemotherapy Survival outcomes Treatment guidelines Urothelial carcinoma funded this work. MK PK and SD are employees of Evidera.

Administration Intravesical BCG Vaccine/*adverse effects/*therapeutic use Humans Meta-Analysis as Topic Randomized Controlled Trials as Topic *Systematic Reviews as Topic Urinary Bladder Neoplasms/*drug therapy

Cystectomy/adverse effects/*methods Disease-Free Survival Follow-Up Studies Humans Incidence Intraoperative Complications/*epidemiology/etiology Length of Stay/statistics & numerical data Neoplasm Recurrence Local/*epidemiology/etiology/prevention & control Randomized Controlled Trials as Topic Urinary Bladder/*injuries/pathology/surgery Urinary Bladder Neoplasms/mortality/pathology/*surgery Bipolar bladder tumors meta-analysis monopolar transurethral resection

Adjuvants Immunologic/administration & dosage Administration Intravesical Antibiotics Antineoplastic/administration & dosage/adverse effects Antimetabolites Antineoplastic/*administration & dosage/adverse effects BCG Vaccine/administration & dosage Bias Cause of Death Confidence Intervals Deoxycytidine/administration & dosage/adverse effects/*analogs & derivatives Disease Progression Drug Administration Schedule Humans Mitomycin/administration & dosage/adverse effects Neoplasm Recurrence Local/*drug therapy/mortality/prevention & control Randomized Controlled Trials as Topic Saline Solution/administration & dosage Urinary Bladder Neoplasms/*drug therapy/mortality/pathology/prevention & control Gemcitabine

Aged Cystectomy/adverse effects/*methods/statistics & numerical data Humans Male Middle Aged Postoperative Complications Quality of Life Randomized Controlled Trials as Topic Robotic Surgical Procedures/adverse effects/*methods/statistics & numerical data Treatment Outcome Urinary Bladder Neoplasms/*surgery

Administration Intravesical Antibiotics Antineoplastic/*administration & dosage Antimetabolites Antineoplastic/*administration & dosage Deoxycytidine/administration & dosage/*analogs & derivatives Humans Mitomycin/*administration & dosage Neoplasm Invasiveness Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*drug therapy/pathology Gemcitabine Bladder cancer Meta-analysis Mitomycin Systematic evaluation

Administration Intravesical Antibiotics Antineoplastic/administration & dosage/*therapeutic use BCG Vaccine Carcinoma Transitional Cell/*drug therapy Humans Mitomycin/administration & dosage/*therapeutic use Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*drug therapy

Adult Aged Aged 80 and over B7-H1 Antigen/genetics/*immunology Female Humans Immune Checkpoint Inhibitors/*administration & dosage *Immunotherapy Male Middle Aged Programmed Cell Death 1 Receptor/genetics/*immunology Progression-Free Survival Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/genetics/immunology/mortality/*therapy efficacy immunotherapy meta-analysis safety urothelial cancer this study.

Blood Loss Surgical/statistics & numerical data Cystectomy/*methods Humans Length of Stay/statistics & numerical data Lymph Node Excision *Minimally Invasive Surgical Procedures Operative Time Postoperative Complications/epidemiology Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Minimally invasive Open radical cystectomy Randomized controlled trials

Aged Carcinoma Transitional Cell/*surgery *Cystectomy/methods Female Humans *Lymph Node Excision Male Middle Aged Postoperative Complications Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery

Anesthetics Local/*therapeutic use *Cystoscopy Humans Lidocaine/*therapeutic use Male Pain Management/*methods Pain Measurement Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/diagnosis/therapy administration cystoscopy intravesical lidocaine pain procedural urinary bladder neoplasms

Humans Patient Outcome Assessment *Patient Reported Outcome Measures Quality of Life Randomized Controlled Trials as Topic Reproducibility of Results Urinary Bladder Neoplasms/*diagnosis/pathology/psychology/*therapy Early bladder cancer Non-muscle invasive bladder cancer Patient-reported outcome measures Systematic review

Cystectomy/*methods Humans Postoperative Complications/epidemiology Quality of Life Randomized Controlled Trials as Topic Robotic Surgical Procedures/*methods Treatment Outcome Urinary Bladder Neoplasms/*surgery

Cystectomy/*methods Humans *Quality of Life Randomized Controlled Trials as Topic Treatment Outcome Urinary Bladder Neoplasms/*surgery *Urinary Diversion/methods *Urinary Reservoirs Continent Bladder cancer index Bricker Cystectomie radicale Ileal conduit Meta-analysis Méta-analyse Néovessie de substitution Orthotopic neobladder Quality of life Qualité de vie Radical cystectomy Revue systématique Systematic review

Cystectomy/adverse effects/*methods Humans *Minimally Invasive Surgical Procedures Perioperative Period Postoperative Complications Randomized Controlled Trials as Topic *Robotic Surgical Procedures/adverse effects Urinary Bladder Neoplasms/*surgery Bladder cancer Meta-analysis Radical cystectomy Randomized controlled trial Robot-assisted radical cystectomy

Adjuvants Immunologic/administration & dosage Administration Intravesical BCG Vaccine/*adverse effects Chondroitin Sulfates/*administration & dosage Cystitis/chemically induced/pathology/*prevention & control Humans Hyaluronic Acid/*administration & dosage Immunotherapy/*adverse effects Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/pathology/*therapy

Cystectomy/methods/*mortality Humans Lymph Node Excision/methods/*mortality Lymph Nodes/surgery Lymphatic Metastasis Pelvis/pathology Postoperative Complications/etiology Prognosis Randomized Controlled Trials as Topic Survival Rate Treatment Outcome Urinary Bladder Neoplasms/*mortality/pathology/*surgery

*Cancer Survivors Humans *Quality of Life Randomized Controlled Trials as Topic Urinary Bladder Neoplasms/*therapy

Administration Intravesical Antineoplastic Agents/administration & dosage Combined Modality Therapy Cystectomy/methods Humans Randomized Controlled Trials as Topic Saline Solution/*administration & dosage/adverse effects Therapeutic Irrigation/adverse effects/methods Treatment Outcome Urethra Urinary Bladder Neoplasms/drug therapy/surgery/*therapy Continuous saline bladder irrigation Meta-analysis Non-muscle invasive bladder cancer Randomized controlled trials Transurethral resection of bladder tumors

Diabetes Mellitus Type 2/complications/drug therapy Humans Hypoglycemic Agents/*adverse effects/therapeutic use Odds Ratio Pioglitazone/*adverse effects/therapeutic use Randomized Controlled Trials as Topic Risk Assessment Risk Factors Time Factors Urinary Bladder Neoplasms/*etiology Bladder cancer dose-response relationship meta-analysis pioglitazone