Adult Caffeine/*adverse effects Central Nervous System Stimulants/adverse effects Coffee/*adverse effects Cytochrome P-450 CYP1A2 Dose-Response Relationship Drug Female Humans Male Middle Aged Risk Factors Smoking/*adverse effects Urinary Bladder Neoplasms/*etiology Bladder cancer Coffee consumption Cohort study Dose–response analyses Smoking

Chemotherapy Adjuvant *Cystectomy/methods Humans Neoadjuvant Therapy Smoking/*adverse effects Survival Rate Treatment Outcome Urinary Bladder Neoplasms/drug therapy/*mortality/*surgery cigarette smoking cystectomy recurrence survival urinary bladder neoplasms

Arylsulfotransferase/*genetics Case-Control Studies Genetic Association Studies Genetic Predisposition to Disease Genotype Humans NAD(P)H Dehydrogenase (Quinone)/*genetics Odds Ratio *Polymorphism Genetic Risk Factors Smoking/*adverse effects Urinary Bladder Neoplasms/enzymology/*genetics Nqo1 Sult1a1 meta-analysis polymorphisms smoking urinary bladder neoplasms

Carcinogenesis Carcinoma Renal Cell/*epidemiology/mortality Humans Kidney Neoplasms/*epidemiology/mortality Tobacco Smoking/*adverse effects Urinary Bladder Neoplasms/*epidemiology/mortality Bladder cancer Kidney cancer Tobacco smoking

Asian People/*statistics & numerical data Case-Control Studies Cohort Studies Confounding Factors Epidemiologic Epidemiologic Studies Humans Japan/epidemiology Research Design Risk Factors Smoking/*adverse effects/*epidemiology Smoking Cessation Urinary Bladder Neoplasms/*epidemiology/etiology Japanese bladder cancer cigarette smoking epidemiology systematic review